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Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR.
Laboute T, Zucca S, Holcomb M, Patil DN, Garza C, Wheatley BA, Roy RN, Forli S, Martemyanov KA. Laboute T, et al. Among authors: zucca s. Science. 2023 Mar 31;379(6639):1352-1358. doi: 10.1126/science.add7150. Epub 2023 Mar 30. Science. 2023. PMID: 36996198 Free PMC article.
Genetic behavioral screen identifies an orphan anti-opioid system.
Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA. Wang D, et al. Among authors: zucca s. Science. 2019 Sep 20;365(6459):1267-1273. doi: 10.1126/science.aau2078. Epub 2019 Aug 15. Science. 2019. PMID: 31416932 Free PMC article.
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects.
Stoveken HM, Zucca S, Masuho I, Grill B, Martemyanov KA. Stoveken HM, et al. Among authors: zucca s. J Biol Chem. 2020 Jul 31;295(31):10822-10830. doi: 10.1074/jbc.AC120.014770. Epub 2020 Jun 23. J Biol Chem. 2020. PMID: 32576659 Free PMC article.
Critical assessment of variant prioritization methods for rare disease diagnosis within the rare genomes project.
Stenton SL, O'Leary MC, Lemire G, VanNoy GE, DiTroia S, Ganesh VS, Groopman E, O'Heir E, Mangilog B, Osei-Owusu I, Pais LS, Serrano J, Singer-Berk M, Weisburd B, Wilson MW, Austin-Tse C, Abdelhakim M, Althagafi A, Babbi G, Bellazzi R, Bovo S, Carta MG, Casadio R, Coenen PJ, De Paoli F, Floris M, Gajapathy M, Hoehndorf R, Jacobsen JOB, Joseph T, Kamandula A, Katsonis P, Kint C, Lichtarge O, Limongelli I, Lu Y, Magni P, Mamidi TKK, Martelli PL, Mulargia M, Nicora G, Nykamp K, Pejaver V, Peng Y, Pham THC, Podda MS, Rao A, Rizzo E, Saipradeep VG, Savojardo C, Schols P, Shen Y, Sivadasan N, Smedley D, Soru D, Srinivasan R, Sun Y, Sunderam U, Tan W, Tiwari N, Wang X, Wang Y, Williams A, Worthey EA, Yin R, You Y, Zeiberg D, Zucca S, Bakolitsa C, Brenner SE, Fullerton SM, Radivojac P, Rehm HL, O'Donnell-Luria A. Stenton SL, et al. Among authors: zucca s. Hum Genomics. 2024 Apr 29;18(1):44. doi: 10.1186/s40246-024-00604-w. Hum Genomics. 2024. PMID: 38685113 Free PMC article.
88 results