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The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML.
Gerlach D, Tontsch-Grunt U, Baum A, Popow J, Scharn D, Hofmann MH, Engelhardt H, Kaya O, Beck J, Schweifer N, Gerstberger T, Zuber J, Savarese F, Kraut N. Gerlach D, et al. Among authors: zuber j. Oncogene. 2018 May;37(20):2687-2701. doi: 10.1038/s41388-018-0150-2. Epub 2018 Mar 1. Oncogene. 2018. PMID: 29491412 Free PMC article.
Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia.
Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N. Rudolph D, et al. Among authors: zuber j. J Pharmacol Exp Ther. 2015 Mar;352(3):579-89. doi: 10.1124/jpet.114.221150. Epub 2015 Jan 9. J Pharmacol Exp Ther. 2015. PMID: 25576074
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryń ŁM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, Valent P, Stark A, Kraut N, Vakoc CR, Zuber J. Rathert P, et al. Among authors: zuber j. Nature. 2015 Sep 24;525(7570):543-547. doi: 10.1038/nature14898. Epub 2015 Sep 14. Nature. 2015. PMID: 26367798 Free PMC article.
Synthetic lethality between the cohesin subunits STAG1 and STAG2 in diverse cancer contexts.
van der Lelij P, Lieb S, Jude J, Wutz G, Santos CP, Falkenberg K, Schlattl A, Ban J, Schwentner R, Hoffmann T, Kovar H, Real FX, Waldman T, Pearson MA, Kraut N, Peters JM, Zuber J, Petronczki M. van der Lelij P, et al. Among authors: zuber j. Elife. 2017 Jul 10;6:e26980. doi: 10.7554/eLife.26980. Elife. 2017. PMID: 28691904 Free PMC article.
SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis.
Muhar M, Ebert A, Neumann T, Umkehrer C, Jude J, Wieshofer C, Rescheneder P, Lipp JJ, Herzog VA, Reichholf B, Cisneros DA, Hoffmann T, Schlapansky MF, Bhat P, von Haeseler A, Köcher T, Obenauf AC, Popow J, Ameres SL, Zuber J. Muhar M, et al. Among authors: zuber j. Science. 2018 May 18;360(6390):800-805. doi: 10.1126/science.aao2793. Epub 2018 Apr 5. Science. 2018. PMID: 29622725 Free PMC article.
Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis.
Schlager S, Salomon C, Olt S, Albrecht C, Ebert A, Bergner O, Wachter J, Trapani F, Gerlach D, Voss T, Traunbauer A, Jude J, Hinterndorfer M, Minnich M, Schweifer N, Blake SM, Zinzalla V, Drobits B, McConnell DB, Kraut N, Pearson M, Zuber J, Koegl M. Schlager S, et al. Among authors: zuber j. Oncotarget. 2020 Mar 3;11(9):875-890. doi: 10.18632/oncotarget.27506. eCollection 2020 Mar 3. Oncotarget. 2020. PMID: 32180900 Free PMC article.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
van der Lelij P, Newman JA, Lieb S, Jude J, Katis V, Hoffmann T, Hinterndorfer M, Bader G, Kraut N, Pearson MA, Peters JM, Zuber J, Gileadi O, Petronczki M. van der Lelij P, et al. Among authors: zuber j. Life Sci Alliance. 2020 May 28;3(7):e202000725. doi: 10.26508/lsa.202000725. Print 2020 Jul. Life Sci Alliance. 2020. PMID: 32467316 Free PMC article.
Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis.
Diesch J, Le Pannérer MM, Winkler R, Casquero R, Muhar M, van der Garde M, Maher M, Herráez CM, Bech-Serra JJ, Fellner M, Rathert P, Brooks N, Zamora L, Gentilella A, de la Torre C, Zuber J, Götze KS, Buschbeck M. Diesch J, et al. Among authors: zuber j. Nat Commun. 2021 Oct 18;12(1):6060. doi: 10.1038/s41467-021-26258-z. Nat Commun. 2021. PMID: 34663789 Free PMC article.
401 results