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Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H, Manco M, Calvani M, Castagneto M, Palacín M, Mingrone G, Zierath JR, Vidal H, Zorzano A. Bach D, et al. Among authors: zorzano a. Diabetes. 2005 Sep;54(9):2685-93. doi: 10.2337/diabetes.54.9.2685. Diabetes. 2005. PMID: 16123358
Genes involved in mitochondrial biogenesis/function are induced in response to bilio-pancreatic diversion in morbidly obese individuals with normal glucose tolerance but not in type 2 diabetic patients.
Hernández-Alvarez MI, Chiellini C, Manco M, Naon D, Liesa M, Palacín M, Mingrone G, Zorzano A. Hernández-Alvarez MI, et al. Among authors: zorzano a. Diabetologia. 2009 Aug;52(8):1618-27. doi: 10.1007/s00125-009-1403-y. Epub 2009 Jun 6. Diabetologia. 2009. PMID: 19504086 Free article.
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity.
Hernández-Alvarez MI, Thabit H, Burns N, Shah S, Brema I, Hatunic M, Finucane F, Liesa M, Chiellini C, Naon D, Zorzano A, Nolan JJ. Hernández-Alvarez MI, et al. Among authors: zorzano a. Diabetes Care. 2010 Mar;33(3):645-51. doi: 10.2337/dc09-1305. Epub 2009 Dec 23. Diabetes Care. 2010. PMID: 20032281 Free PMC article. Clinical Trial.
The DEXLIFE study methods: identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals.
Andersen GS, Thybo T, Cederberg H, Orešič M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ; DEXLIFE Consortium. Andersen GS, et al. Among authors: zorzano a. Diabetes Res Clin Pract. 2014 Nov;106(2):383-9. doi: 10.1016/j.diabres.2014.07.025. Epub 2014 Jul 27. Diabetes Res Clin Pract. 2014. PMID: 25125339 Clinical Trial.
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism.
Hernández-Alvarez MI, Díaz-Ramos A, Berdasco M, Cobb J, Planet E, Cooper D, Pazderska A, Wanic K, O'Hanlon D, Gomez A, de la Ballina LR, Esteller M, Palacin M, O'Gorman DJ, Nolan JJ, Zorzano A. Hernández-Alvarez MI, et al. Among authors: zorzano a. Sci Rep. 2017 Oct 23;7(1):13850. doi: 10.1038/s41598-017-14120-6. Sci Rep. 2017. PMID: 29062026 Free PMC article.
372 results