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Rapid macropinocytic transfer of α-synuclein to lysosomes.
Bayati A, Banks E, Han C, Luo W, Reintsch WE, Zorca CE, Shlaifer I, Del Cid Pellitero E, Vanderperre B, McBride HM, Fon EA, Durcan TM, McPherson PS. Bayati A, et al. Among authors: zorca ce. Cell Rep. 2022 Jul 19;40(3):111102. doi: 10.1016/j.celrep.2022.111102. Cell Rep. 2022. PMID: 35858558 Free article.
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.
Senkevich K, Zorca CE, Dworkind A, Rudakou U, Somerville E, Yu E, Ermolaev A, Nikanorova D, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Grenn FP, Chiang MSR, Sardi SP, Vanderperre B, Blauwendraat C, Trempe JF, Fon EA, Durcan TM, Alcalay RN, Gan-Or Z. Senkevich K, et al. Among authors: zorca ce. Brain. 2023 May 2;146(5):1859-1872. doi: 10.1093/brain/awac413. Brain. 2023. PMID: 36370000 Free PMC article.
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress.
Eldeeb MA, Bayne AN, Fallahi A, Goiran T, MacDougall EJ, Soumbasis A, Zorca CE, Tabah JJ, Thomas RA, Karpilovsky N, Mathur M, Durcan TM, Trempe JF, Fon EA. Eldeeb MA, et al. Among authors: zorca ce. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2313540121. doi: 10.1073/pnas.2313540121. Epub 2024 Feb 28. Proc Natl Acad Sci U S A. 2024. PMID: 38416681 Free PMC article.
Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.
Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G. Lessard F, et al. Among authors: zorca ce. Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25. Nat Cell Biol. 2018. PMID: 29941930
Targeting Cancer Cells via N-degron-based PROTACs.
Eldeeb MA, Zorca CE, Fahlman RP. Eldeeb MA, et al. Among authors: zorca ce. Endocrinology. 2020 Dec 1;161(12):bqaa185. doi: 10.1210/endocr/bqaa185. Endocrinology. 2020. PMID: 33159513
16 results