Zhu J - Search Results

1

Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one.

Luo Y, Li J, Zong Y, Sun M, Zheng W, Zhu J, Liu L, Liu B. Luo Y, et al. Among authors: zhu j. J Enzyme Inhib Med Chem. 2023 Dec;38(1):398-404. doi: 10.1080/14756366.2022.2151594. J Enzyme Inhib Med Chem. 2023. PMID: 36476046 Free PMC article.

2

Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial-mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway.

Zhang Z, Xu J, Liu B, Chen F, Li J, Liu Y, Zhu J, Shen C. Zhang Z, et al. Among authors: zhu j. Inflammopharmacology. 2019 Jun;27(3):627-638. doi: 10.1007/s10787-018-0534-5. Epub 2018 Sep 22. Inflammopharmacology. 2019. PMID: 30244296

3

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.

Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D, Li H, Ma Y, Xu J, Chen H, Cui Y, Zhi Y, Zhang Y, Xu J, Zhu J, Lu T, Chen Y. Jiang F, et al. Among authors: zhu j. J Med Chem. 2019 Dec 26;62(24):11080-11107. doi: 10.1021/acs.jmedchem.9b01010. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31789032

4

Structure of the cytochrome aa₃ -600 heme-copper menaquinol oxidase bound to inhibitor HQNO shows TM0 is part of the quinol binding site.

Xu J, Ding Z, Liu B, Yi SM, Li J, Zhang Z, Liu Y, Li J, Liu L, Zhou A, Gennis RB, Zhu J. Xu J, et al. Among authors: zhu j. Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):872-876. doi: 10.1073/pnas.1915013117. Epub 2019 Dec 30. Proc Natl Acad Sci U S A. 2020. PMID: 31888984 Free PMC article.

5

Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor.

Li J, Zou W, Yu K, Liu B, Liang W, Wang L, Lu Y, Jiang Z, Wang A, Zhu J. Li J, et al. Among authors: zhu j. J Enzyme Inhib Med Chem. 2021 Dec;36(1):903-913. doi: 10.1080/14756366.2021.1906663. J Enzyme Inhib Med Chem. 2021. PMID: 33820450 Free PMC article.

6

Identification and confirmation of 14-3-3 ζ as a novel target of ginsenosides in brain tissues.

Chen F, Chen L, Liang W, Zhang Z, Li J, Zheng W, Zhu Z, Zhu J, Zhao Y. Chen F, et al. Among authors: zhu z, zhu j. J Ginseng Res. 2021 Jul;45(4):465-472. doi: 10.1016/j.jgr.2020.12.007. Epub 2020 Dec 29. J Ginseng Res. 2021. PMID: 34295206 Free PMC article.

7

Cryo-EM structures of Escherichia coli cytochrome bo₃ reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site.

Li J, Han L, Vallese F, Ding Z, Choi SK, Hong S, Luo Y, Liu B, Chan CK, Tajkhorshid E, Zhu J, Clarke O, Zhang K, Gennis R. Li J, et al. Among authors: zhu j. Proc Natl Acad Sci U S A. 2021 Aug 24;118(34):e2106750118. doi: 10.1073/pnas.2106750118. Proc Natl Acad Sci U S A. 2021. PMID: 34417297 Free PMC article.

8

Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy.

Kong B, Zhu Z, Li H, Hong Q, Wang C, Ma Y, Zheng W, Jiang F, Zhang Z, Ran T, Bian Y, Yang N, Lu T, Zhu J, Tang W, Chen Y. Kong B, et al. Among authors: zhu z, zhu j. Eur J Med Chem. 2022 Jan 5;227:113953. doi: 10.1016/j.ejmech.2021.113953. Epub 2021 Oct 29. Eur J Med Chem. 2022. PMID: 34731760

9

Alteration of the Catalytic Reaction Trajectory of a Vicinal Oxygen Chelate Enzyme by Directed Evolution.

Wang YS, Zheng W, Jiang N, Jin YX, Meng ZK, Sun MX, Zong YL, Xu T, Zhu J, Tan RX. Wang YS, et al. Among authors: zhu j. Angew Chem Int Ed Engl. 2022 Jun 27;61(26):e202201321. doi: 10.1002/anie.202201321. Epub 2022 Apr 27. Angew Chem Int Ed Engl. 2022. PMID: 35415958

10

Structures of the CcmABCD heme release complex at multiple states.

Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J. Li J, et al. Among authors: zhu j. Nat Commun. 2022 Oct 28;13(1):6422. doi: 10.1038/s41467-022-34136-5. Nat Commun. 2022. PMID: 36307425 Free PMC article.

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