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Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Zhang B, Wang KB, Wang W, Wang X, Liu F, Zhu J, Shi J, Li LY, Han H, Xu K, Qiao HY, Zhang X, Jiao RH, Houk KN, Liang Y, Tan RX, Ge HM. Zhang B, et al. Among authors: zhu j. Nature. 2019 Apr;568(7750):122-126. doi: 10.1038/s41586-019-1021-x. Epub 2019 Mar 13. Nature. 2019. PMID: 30867595 Free PMC article.
Genome mining and biosynthesis of kitacinnamycins as a STING activator.
Shi J, Liu CL, Zhang B, Guo WJ, Zhu J, Chang CY, Zhao EJ, Jiao RH, Tan RX, Ge HM. Shi J, et al. Among authors: zhu j. Chem Sci. 2019 Apr 2;10(18):4839-4846. doi: 10.1039/c9sc00815b. eCollection 2019 May 14. Chem Sci. 2019. PMID: 31160959 Free PMC article.
Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.
Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D, Li H, Ma Y, Xu J, Chen H, Cui Y, Zhi Y, Zhang Y, Xu J, Zhu J, Lu T, Chen Y. Jiang F, et al. Among authors: zhu j. J Med Chem. 2019 Dec 26;62(24):11080-11107. doi: 10.1021/acs.jmedchem.9b01010. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31789032
Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the Selectivity for the Second Bromodomain (BD2) and the Capacity for the Treatment of Inflammatory Diseases.
Wang Z, Yin L, Xiong Z, Huang F, Yang N, Jiang F, Li H, Cui Y, Ren J, Cheng Z, Jia K, Lu T, Zhu J, Hu Q, Chen Y. Wang Z, et al. Among authors: zhu j. J Med Chem. 2023 Aug 10;66(15):10824-10848. doi: 10.1021/acs.jmedchem.3c01028. Epub 2023 Jul 21. J Med Chem. 2023. PMID: 37478496
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