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Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells.
Jia Y, Han L, Ramage CL, Wang Z, Weng CC, Yang L, Colla S, Ma H, Zhang W, Andreeff M, Daver N, Jain N, Pemmaraju N, Bhalla K, Mustjoki S, Zhang P, Zheng G, Zhou D, Zhang Q, Konopleva M. Jia Y, et al. Among authors: zheng g. Haematologica. 2023 Oct 1;108(10):2626-2638. doi: 10.3324/haematol.2022.281915. Haematologica. 2023. PMID: 37078252 Free PMC article.
Piperlongumine conjugates induce targeted protein degradation.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, Zhou S, Hua N, Mackintosh SG, Zhang X, Basso KB, Kamat M, Yang Q, Licht JD, Zheng G, Zhou D, Lv D. Pei J, et al. Among authors: zheng g. Cell Chem Biol. 2023 Feb 16;30(2):203-213.e17. doi: 10.1016/j.chembiol.2023.01.004. Epub 2023 Feb 6. Cell Chem Biol. 2023. PMID: 36750097 Free PMC article.
Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy.
Wang L, Xiao Y, Luo Y, Master RP, Mo J, Kim MC, Liu Y, Patel UM, Li X, Shaffer D, Guertin KR, Moser E, Smalley KS, Zhou D, Zheng G, Zhang W. Wang L, et al. Among authors: zheng g. bioRxiv [Preprint]. 2023 Aug 13:2023.08.09.552650. doi: 10.1101/2023.08.09.552650. bioRxiv. 2023. PMID: 37609171 Free PMC article. Updated. Preprint.
PROTAC therapy as a new targeted therapy for lung cancer.
Li JW, Zheng G, Kaye FJ, Wu L. Li JW, et al. Among authors: zheng g. Mol Ther. 2023 Mar 1;31(3):647-656. doi: 10.1016/j.ymthe.2022.11.011. Epub 2022 Nov 22. Mol Ther. 2023. PMID: 36415148 Free PMC article. Review.
5,672 results