Zhao L - Search Results

1

Design, Synthesis, and Evaluation of o-(Biphenyl-3-ylmethoxy)nitrophenyl Derivatives as PD-1/PD-L1 Inhibitors with Potent Anticancer Efficacy In Vivo.

OuYang Y, Gao J, Zhao L, Lu J, Zhong H, Tang H, Jin S, Yue L, Li Y, Guo W, Xu Q, Lai Y. OuYang Y, et al. Among authors: zhao l. J Med Chem. 2021 Jun 10;64(11):7646-7666. doi: 10.1021/acs.jmedchem.1c00370. Epub 2021 May 26. J Med Chem. 2021. PMID: 34037385

2

Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.

Wang K, Lei Z, Zhao L, Chen B, Yang F, Liu K, Zhu H, Zhao H, Cao R, Zhang K, Tian Y. Wang K, et al. Among authors: zhao h, zhao l. Eur J Med Chem. 2020 Jan 1;185:111841. doi: 10.1016/j.ejmech.2019.111841. Epub 2019 Nov 2. Eur J Med Chem. 2020. PMID: 31708183

3

Design, synthesis and evaluation of novel ErbB/HDAC multitargeted inhibitors with selectivity in EGFR^T790M mutant cell lines.

Zhao L, Fan T, Shi Z, Ding C, Zhang C, Yuan Z, Sun Q, Tan C, Chu B, Jiang Y. Zhao L, et al. Eur J Med Chem. 2021 Mar 5;213:113173. doi: 10.1016/j.ejmech.2021.113173. Epub 2021 Jan 18. Eur J Med Chem. 2021. PMID: 33493830

4

Benzothiazole-based compounds as potent endothelial lipase inhibitors.

Meng W, Adam LP, Behnia K, Zhao L, Yang R, Kopcho LM, Locke GA, Taylor DS, Yin X, Wexler RR, Finlay H. Meng W, et al. Among authors: zhao l. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126673. doi: 10.1016/j.bmcl.2019.126673. Epub 2019 Sep 6. Bioorg Med Chem Lett. 2019. PMID: 31519373

5

New phorbol ester derivatives as potent anti-HIV agents.

Li QR, Cheng YY, Zhao L, Huang XL, Jiang XG, Cui YD, Morris-Natschke SL, Goto M, Chen CH, Lee KH, Chen DF, Zhang J. Li QR, et al. Among authors: zhao l. Bioorg Med Chem Lett. 2021 Oct 15;50:128319. doi: 10.1016/j.bmcl.2021.128319. Epub 2021 Aug 14. Bioorg Med Chem Lett. 2021. PMID: 34403728

6

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery.

Wang C, Zhao L, Xia S, Zhang T, Cao R, Liang G, Li Y, Meng G, Wang W, Shi W, Zhong W, Jiang S, Liu K. Wang C, et al. Among authors: zhao l. J Med Chem. 2018 Oct 11;61(19):8734-8745. doi: 10.1021/acs.jmedchem.8b00890. Epub 2018 Sep 19. J Med Chem. 2018. PMID: 30192544 Free PMC article.

7

Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.

Tora G, Kim SH, Pi Z, Johnson JA, Jiang J, Phillips M, Lloyd J, Abell LM, Lu H, Locke G, Adam LP, Taylor DS, Yin X, Behnia K, Zhao L, Yang R, Basso M, Caporuscio C, Chen AY, Liu E, Kirshgessner T, Onorato JM, Ryan C, Traeger SC, Gordon D, Wexler RR, Finlay HJ. Tora G, et al. Among authors: zhao l. J Med Chem. 2020 Feb 27;63(4):1660-1670. doi: 10.1021/acs.jmedchem.9b01831. Epub 2020 Feb 11. J Med Chem. 2020. PMID: 31990537

8

Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds.

Xu L, Zhao L, Che J, Zhang Q, Cao R, Li X. Xu L, et al. Among authors: zhao l. Bioorg Med Chem. 2021 Dec 15;52:116515. doi: 10.1016/j.bmc.2021.116515. Epub 2021 Nov 11. Bioorg Med Chem. 2021. PMID: 34839161

9

Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.

Shaw SA, Vokits BP, Dilger AK, Viet A, Clark CG, Abell LM, Locke GA, Duke G, Kopcho LM, Dongre A, Gao J, Krishnakumar A, Jusuf S, Khan J, Spronk SA, Basso MD, Zhao L, Cantor GH, Onorato JM, Wexler RR, Duclos F, Kick EK. Shaw SA, et al. Among authors: zhao l. Bioorg Med Chem. 2020 Nov 15;28(22):115723. doi: 10.1016/j.bmc.2020.115723. Epub 2020 Sep 1. Bioorg Med Chem. 2020. PMID: 33007547

10

Potent Triazolopyridine Myeloperoxidase Inhibitors.

Wurtz NR, Viet A, Shaw SA, Dilger A, Valente MN, Khan JA, Jusuf S, Narayanan R, Fernando G, Lo F, Liu X, Locke GA, Kopcho L, Abell LM, Sleph P, Basso M, Zhao L, Wexler RR, Duclos F, Kick EK. Wurtz NR, et al. Among authors: zhao l. ACS Med Chem Lett. 2018 Nov 1;9(12):1175-1180. doi: 10.1021/acsmedchemlett.8b00308. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613322 Free PMC article.

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