Zhang Z - Search Results

1

Progress on small-molecule proteolysis-targeting chimeras.

Huang W, Wang B, Zhang Z, Zhang C, Zeng S, Shen Z. Huang W, et al. Among authors: zhang c, zhang z. Future Med Chem. 2019 Oct;11(20):2715-2734. doi: 10.4155/fmc-2019-0161. Epub 2019 Oct 1. Future Med Chem. 2019. PMID: 31571504

2

Antifibrotic effects of a novel pirfenidone derivative in vitro and in vivo.

Ma Z, Zhao C, Chen Q, Yu C, Zhang H, Zhang Z, Huang W, Shen Z. Ma Z, et al. Among authors: zhang z, zhang h. Pulm Pharmacol Ther. 2018 Dec;53:100-106. doi: 10.1016/j.pupt.2018.10.006. Epub 2018 Oct 28. Pulm Pharmacol Ther. 2018. PMID: 30394340

3

Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping.

Zhang Z, Gu L, Wang B, Huang W, Zhang Y, Ma Z, Zeng S, Shen Z. Zhang Z, et al. Among authors: zhang y. J Enzyme Inhib Med Chem. 2019 Dec;34(1):808-817. doi: 10.1080/14756366.2019.1587417. J Enzyme Inhib Med Chem. 2019. PMID: 30879350 Free PMC article.

4

Development of the "hidden" multifunctional agents for Alzheimer's disease.

Huang W, Liang M, Li Q, Zheng X, Zhang C, Wang Q, Tang L, Zhang Z, Wang B, Shen Z. Huang W, et al. Among authors: zhang c, zhang z. Eur J Med Chem. 2019 Sep 1;177:247-258. doi: 10.1016/j.ejmech.2019.05.051. Epub 2019 May 27. Eur J Med Chem. 2019. PMID: 31158742

5

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

Zhi Y, Wang S, Huang W, Zeng S, Liang M, Zhang C, Ma Z, Wang Z, Zhang Z, Shen Z. Zhi Y, et al. Among authors: zhang c, zhang z. Eur J Med Chem. 2019 Oct 1;179:502-514. doi: 10.1016/j.ejmech.2019.06.067. Epub 2019 Jun 28. Eur J Med Chem. 2019. PMID: 31276895

6

Discovery of Benzo[cd]indol-2(1H)-ones and Pyrrolo[4,3,2-de]quinolin-2(1H)-ones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain with Potential High Efficiency against Acute Gouty Arthritis.

Jiang F, Hu Q, Zhang Z, Li H, Li H, Zhang D, Li H, Ma Y, Xu J, Chen H, Cui Y, Zhi Y, Zhang Y, Xu J, Zhu J, Lu T, Chen Y. Jiang F, et al. Among authors: zhang d, zhang z, zhang y. J Med Chem. 2019 Dec 26;62(24):11080-11107. doi: 10.1021/acs.jmedchem.9b01010. Epub 2019 Dec 13. J Med Chem. 2019. PMID: 31789032

7

Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1).

Zhang Z, Chang X, Zhang C, Zeng S, Liang M, Ma Z, Wang Z, Huang W, Shen Z. Zhang Z, et al. Among authors: zhang c. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1606-1615. doi: 10.1080/14756366.2020.1804382. J Enzyme Inhib Med Chem. 2020. PMID: 32779949 Free PMC article.

8

HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development.

Huang W, Wang S, Zhang Z, Zhang C, Zeng S, Liang M, Shen Z, Liu X. Huang W, et al. Among authors: zhang c, zhang z. Bioorg Chem. 2020 Dec;105:104377. doi: 10.1016/j.bioorg.2020.104377. Epub 2020 Oct 13. Bioorg Chem. 2020. PMID: 33091668

9

Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges.

Zeng S, Huang W, Zheng X, Liyan Cheng, Zhang Z, Wang J, Shen Z. Zeng S, et al. Among authors: zhang z. Eur J Med Chem. 2021 Jan 15;210:112981. doi: 10.1016/j.ejmech.2020.112981. Epub 2020 Oct 31. Eur J Med Chem. 2021. PMID: 33160761 Review.

10

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Tan L, Zhang Z, Gao D, Chan S, Luo J, Tu ZC, Zhang ZM, Ding K, Ren X, Lu X. Tan L, et al. Among authors: zhang z, zhang zm. Eur J Med Chem. 2019 Mar 15;166:318-327. doi: 10.1016/j.ejmech.2019.01.065. Epub 2019 Jan 30. Eur J Med Chem. 2019. PMID: 30731400

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