NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation.
Jiang X, Zhang X, Cai X, Li N, Zheng H, Tang M, Zhu J, Su K, Zhang R, Ye N, Peng J, Zhao M, Wu W, Yang J, Ye H.
Jiang X, et al. Among authors: zhang r, zhang x.
Sci Adv. 2024 Feb 9;10(6):eadi9284. doi: 10.1126/sciadv.adi9284. Epub 2024 Feb 7.
Sci Adv. 2024.
PMID: 38324683
Free PMC article.