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The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy.
Hernlund E, Olofsson MH, Fayad W, Fryknäs M, Lesiak-Mieczkowska K, Zhang X, Brnjic S, Schmidt V, D'Arcy P, Sjöblom T, De Milito A, Larsson R, Linder S. Hernlund E, et al. Among authors: zhang x. Eur J Cancer. 2012 Feb;48(3):396-406. doi: 10.1016/j.ejca.2011.11.013. Epub 2011 Dec 7. Eur J Cancer. 2012. PMID: 22154651
Autophagy is a protective mechanism for human melanoma cells under acidic stress.
Marino ML, Pellegrini P, Di Lernia G, Djavaheri-Mergny M, Brnjic S, Zhang X, Hägg M, Linder S, Fais S, Codogno P, De Milito A. Marino ML, et al. Among authors: zhang x. J Biol Chem. 2012 Aug 31;287(36):30664-76. doi: 10.1074/jbc.M112.339127. Epub 2012 Jul 3. J Biol Chem. 2012. PMID: 22761435 Free PMC article.
Iron chelators target both proliferating and quiescent cancer cells.
Fryknäs M, Zhang X, Bremberg U, Senkowski W, Olofsson MH, Brandt P, Persson I, D'Arcy P, Gullbo J, Nygren P, Schughart LK, Linder S, Larsson R. Fryknäs M, et al. Among authors: zhang x. Sci Rep. 2016 Dec 7;6:38343. doi: 10.1038/srep38343. Sci Rep. 2016. PMID: 27924826 Free PMC article.
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