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From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes.
Xu X, Zhang W, Berthelet J, Liu R, Michail C, Chaffotte AF, Dupret JM, Rodrigues-Lima F. Xu X, et al. Among authors: zhang w. Biochem Biophys Res Commun. 2020 Apr 30;525(2):308-312. doi: 10.1016/j.bbrc.2020.02.082. Epub 2020 Feb 20. Biochem Biophys Res Commun. 2020. PMID: 32089267
Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues.
Zhang W, Berthelet J, Michail C, Bui LC, Gou P, Liu R, Duval R, Renault J, Dupret JM, Guidez F, Chomienne C, Rodrigues Lima F. Zhang W, et al. Free Radic Biol Med. 2021 Jan;162:27-37. doi: 10.1016/j.freeradbiomed.2020.11.027. Epub 2020 Dec 2. Free Radic Biol Med. 2021. PMID: 33278510
Cisplatin causes covalent inhibition of protein-tyrosine phosphatase 1B (PTP1B) through reaction with its active site cysteine: Molecular, cellular and in vivo mice studies.
Liu R, Zhang W, Gou P, Berthelet J, Nian Q, Chevreux G, Legros V, Moroy G, Bui LC, Wang L, Dupret JM, Deshayes F, Rodrigues Lima F. Liu R, et al. Among authors: zhang w. Biomed Pharmacother. 2022 Sep;153:113372. doi: 10.1016/j.biopha.2022.113372. Epub 2022 Jul 6. Biomed Pharmacother. 2022. PMID: 35809481 Free article.
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