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Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH. Maddocks ODK, et al. Among authors: zhang t. Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Nature. 2017. PMID: 28425994 Free article.
SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis.
Pranzini E, Pardella E, Muccillo L, Leo A, Nesi I, Santi A, Parri M, Zhang T, Uribe AH, Lottini T, Sabatino L, Caselli A, Arcangeli A, Raugei G, Colantuoni V, Cirri P, Chiarugi P, Maddocks ODK, Paoli P, Taddei ML. Pranzini E, et al. Among authors: zhang t. Cell Rep. 2022 Aug 16;40(7):111233. doi: 10.1016/j.celrep.2022.111233. Cell Rep. 2022. PMID: 35977477 Free article.
Phenotypic profiling of solute carriers characterizes serine transport in cancer.
Papalazarou V, Newman AC, Huerta-Uribe A, Legrave NM, Falcone M, Zhang T, McGarry L, Athineos D, Shanks E, Blyth K, Vousden KH, Maddocks ODK. Papalazarou V, et al. Among authors: zhang t. Nat Metab. 2023 Dec;5(12):2148-2168. doi: 10.1038/s42255-023-00936-2. Epub 2023 Dec 8. Nat Metab. 2023. PMID: 38066114 Free PMC article.
mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. Rabanal-Ruiz Y, et al. Among authors: zhang t. J Cell Biol. 2021 May 3;220(5):e202004010. doi: 10.1083/jcb.202004010. J Cell Biol. 2021. PMID: 33635313 Free PMC article.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: zhang t. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
35,361 results
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