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Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S. Xia A, et al. Among authors: zhang c, zhang s, zhang j. Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2308435120. doi: 10.1073/pnas.2308435120. Epub 2023 Sep 21. Proc Natl Acad Sci U S A. 2023. PMID: 37733739 Free PMC article.
An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Quan BX, Shuai H, Xia AJ, Hou Y, Zeng R, Liu XL, Lin GF, Qiao JX, Li WP, Wang FL, Wang K, Zhou RJ, Yuen TT, Chen MX, Yoon C, Wu M, Zhang SY, Huang C, Wang YF, Yang W, Tian C, Li WM, Wei YQ, Yuen KY, Chan JF, Lei J, Chu H, Yang S. Quan BX, et al. Among authors: zhang sy. Nat Microbiol. 2022 May;7(5):716-725. doi: 10.1038/s41564-022-01119-7. Epub 2022 Apr 27. Nat Microbiol. 2022. PMID: 35477751
Discovery of 4-(1,2,4-Oxadiazol-5-yl)azepan-2-one Derivatives as a New Class of Cannabinoid Type 2 Receptor Agonists for the Treatment of Inflammatory Pain.
Nan J, Liu J, Lin G, Zhang S, Xia A, Zhou P, Zhou Y, Zhang J, Zhao J, Zhang S, Huang C, Wang Y, Hu Q, Chen J, Xiang M, Yang X, Yang S. Nan J, et al. Among authors: zhang s, zhang j. J Med Chem. 2023 Mar 9;66(5):3460-3483. doi: 10.1021/acs.jmedchem.2c01943. Epub 2023 Feb 23. J Med Chem. 2023. PMID: 36821347
A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants.
Huang C, Shuai H, Qiao J, Hou Y, Zeng R, Xia A, Xie L, Fang Z, Li Y, Yoon C, Huang Q, Hu B, You J, Quan B, Zhao X, Guo N, Zhang S, Ma R, Zhang J, Wang Y, Yang R, Zhang S, Nan J, Xu H, Wang F, Lei J, Chu H, Yang S. Huang C, et al. Among authors: zhang s, zhang j. Signal Transduct Target Ther. 2023 Mar 16;8(1):128. doi: 10.1038/s41392-023-01392-w. Signal Transduct Target Ther. 2023. PMID: 36928316 Free PMC article.
Second-line treatment options in metastatic castration-resistant prostate cancer after progression on first-line androgen-receptor targeting therapies: A systematic review and Bayesian network analysis.
Xiong X, Zhang S, Zheng W, Liao X, Yang J, Xu H, Hu S, Wei Q, Yang L. Xiong X, et al. Among authors: zhang s. Crit Rev Oncol Hematol. 2024 Apr;196:104286. doi: 10.1016/j.critrevonc.2024.104286. Epub 2024 Feb 3. Crit Rev Oncol Hematol. 2024. PMID: 38316286 Review.
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