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Liver homeostasis is maintained by midlobular zone 2 hepatocytes.
Wei Y, Wang YG, Jia Y, Li L, Yoon J, Zhang S, Wang Z, Zhang Y, Zhu M, Sharma T, Lin YH, Hsieh MH, Albrecht JH, Le PT, Rosen CJ, Wang T, Zhu H. Wei Y, et al. Among authors: zhang s, zhang y. Science. 2021 Feb 26;371(6532):eabb1625. doi: 10.1126/science.abb1625. Science. 2021. PMID: 33632817 Free PMC article.
The origins and functions of hepatic polyploidy.
Zhang S, Lin YH, Tarlow B, Zhu H. Zhang S, et al. Cell Cycle. 2019 Jun;18(12):1302-1315. doi: 10.1080/15384101.2019.1618123. Epub 2019 May 26. Cell Cycle. 2019. PMID: 31096847 Free PMC article. Review.
Mice With Increased Numbers of Polyploid Hepatocytes Maintain Regenerative Capacity But Develop Fewer Hepatocellular Carcinomas Following Chronic Liver Injury.
Lin YH, Zhang S, Zhu M, Lu T, Chen K, Wen Z, Wang S, Xiao G, Luo D, Jia Y, Li L, MacConmara M, Hoshida Y, Singal AG, Yopp A, Wang T, Zhu H. Lin YH, et al. Among authors: zhang s. Gastroenterology. 2020 May;158(6):1698-1712.e14. doi: 10.1053/j.gastro.2020.01.026. Epub 2020 Jan 20. Gastroenterology. 2020. PMID: 31972235 Free PMC article.
Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.
Zhang S, Nguyen LH, Zhou K, Tu HC, Sehgal A, Nassour I, Li L, Gopal P, Goodman J, Singal AG, Yopp A, Zhang Y, Siegwart DJ, Zhu H. Zhang S, et al. Among authors: zhang y. Gastroenterology. 2018 Apr;154(5):1421-1434. doi: 10.1053/j.gastro.2017.12.013. Epub 2017 Dec 21. Gastroenterology. 2018. PMID: 29274368 Free PMC article.
Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.
Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H. Sun X, et al. Among authors: zhang s. Cancer Cell. 2017 Nov 13;32(5):574-589.e6. doi: 10.1016/j.ccell.2017.10.007. Cancer Cell. 2017. PMID: 29136504 Free PMC article.
The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal P, Tarlow BD, Siegwart DJ, Zhu H. Zhang S, et al. Among authors: zhang y. Dev Cell. 2018 Feb 26;44(4):447-459.e5. doi: 10.1016/j.devcel.2018.01.010. Epub 2018 Feb 8. Dev Cell. 2018. PMID: 29429824 Free PMC article.
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