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PRMT5 activates AKT via methylation to promote tumor metastasis.
Huang L, Zhang XO, Rozen EJ, Sun X, Sallis B, Verdejo-Torres O, Wigglesworth K, Moon D, Huang T, Cavaretta JP, Wang G, Zhang L, Shohet JM, Lee MM, Wu Q. Huang L, et al. Among authors: zhang xo, zhang l. Nat Commun. 2022 Jul 8;13(1):3955. doi: 10.1038/s41467-022-31645-1. Nat Commun. 2022. PMID: 35803962 Free PMC article.
Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle.
Hu SH, Feng YY, Yang YX, Ma HD, Zhou SX, Qiao YN, Zhang KH, Zhang L, Huang L, Yuan YY, Lin Y, Zhang XY, Li Y, Li HT, Zhao JY, Xu W, Zhao SM. Hu SH, et al. Among authors: zhang l, zhang kh, zhang xy. Nat Metab. 2023 Apr;5(4):626-641. doi: 10.1038/s42255-023-00784-0. Epub 2023 Apr 20. Nat Metab. 2023. PMID: 37081161
POH1 induces Smad3 deubiquitination and promotes lung cancer metastasis.
Yuan Y, Li Y, Wu X, Bo J, Zhang L, Zhang J, Hu Y, Chen Y, Zeng Y, Wei X, Zhang H. Yuan Y, et al. Among authors: zhang l, zhang j, zhang h. Cancer Lett. 2024 Feb 1;582:216526. doi: 10.1016/j.canlet.2023.216526. Epub 2023 Dec 5. Cancer Lett. 2024. PMID: 38061486 Free article.
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