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1,781 results

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Page 1
De novo design of luciferases using deep learning.
Yeh AH, Norn C, Kipnis Y, Tischer D, Pellock SJ, Evans D, Ma P, Lee GR, Zhang JZ, Anishchenko I, Coventry B, Cao L, Dauparas J, Halabiya S, DeWitt M, Carter L, Houk KN, Baker D. Yeh AH, et al. Among authors: zhang jz. Nature. 2023 Feb;614(7949):774-780. doi: 10.1038/s41586-023-05696-3. Epub 2023 Feb 22. Nature. 2023. PMID: 36813896 Free PMC article.
Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system.
Zhang JZ, Yeh HW, Walls AC, Wicky BIM, Sprouse K, VanBlargan LA, Treger R, Quijano-Rubio A, Pham MN, Kraft JC, Haydon IC, Yang W, DeWitt M, Chow C, Carter L, Wener MH, Stewart L, Veesler D, Diamond MS, Baker D. Zhang JZ, et al. bioRxiv [Preprint]. 2021 Jun 22:2021.06.22.449355. doi: 10.1101/2021.06.22.449355. bioRxiv. 2021. PMID: 34189528 Free PMC article. Updated. Preprint.
Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants.
Zhang JZ, Yeh HW, Walls AC, Wicky BIM, Sprouse KR, VanBlargan LA, Treger R, Quijano-Rubio A, Pham MN, Kraft JC, Haydon IC, Yang W, DeWitt M, Bowen JE, Chow CM, Carter L, Ravichandran R, Wener MH, Stewart L, Veesler D, Diamond MS, Greninger AL, Koelle DM, Baker D. Zhang JZ, et al. Nat Biotechnol. 2022 Sep;40(9):1336-1340. doi: 10.1038/s41587-022-01280-8. Epub 2022 Apr 28. Nat Biotechnol. 2022. PMID: 35484405 Free PMC article.
De novo designed Hsp70 activator dissolves intracellular condensates.
Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D. Zhang JZ, et al. bioRxiv [Preprint]. 2023 Sep 19:2023.09.18.558356. doi: 10.1101/2023.09.18.558356. bioRxiv. 2023. PMID: 37781598 Free PMC article. Preprint.
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
Huang B, Abedi M, Ahn G, Coventry B, Sappington I, Wang R, Schlichthaerle T, Zhang JZ, Wang Y, Goreshnik I, Chiu CW, Chazin-Gray A, Chan S, Gerben S, Murray A, Wang S, O'Neill J, Yeh R, Misquith A, Wolf A, Tomasovic LM, Piraner DI, Gonzalez MJD, Bennett NR, Venkatesh P, Satoe D, Ahlrichs M, Dobbins C, Yang W, Wang X, Vafeados D, Mout R, Shivaei S, Cao L, Carter L, Stewart L, Spangler JB, Bernardes GJL, Roybal KT, Greisen P Jr, Li X, Bertozzi C, Baker D. Huang B, et al. Among authors: zhang jz. bioRxiv [Preprint]. 2023 Sep 20:2023.08.19.553321. doi: 10.1101/2023.08.19.553321. bioRxiv. 2023. PMID: 37781607 Free PMC article. Preprint.
Computational design of non-porous, pH-responsive antibody nanoparticles.
Yang EC, Divine R, Miranda MC, Borst AJ, Sheffler W, Zhang JZ, Decarreau J, Saragovi A, Abedi M, Goldbach N, Ahlrichs M, Dobbins C, Hand A, Cheng S, Lamb M, Levine PM, Chan S, Skotheim R, Fallas J, Ueda G, Lubner J, Somiya M, Khmelinskaia A, King NP, Baker D. Yang EC, et al. Among authors: zhang jz. bioRxiv [Preprint]. 2023 Apr 18:2023.04.17.537263. doi: 10.1101/2023.04.17.537263. bioRxiv. 2023. PMID: 37131615 Free PMC article. Preprint.
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice.
Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. Zhang JF, et al. Among authors: zhang j, zhang jz. Nat Chem Biol. 2021 Jan;17(1):39-46. doi: 10.1038/s41589-020-00660-y. Epub 2020 Sep 28. Nat Chem Biol. 2021. PMID: 32989297 Free PMC article.
1,781 results