Zhang J - Search Results

1

Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport.

Zhang J, Karimy JK, Delpire E, Kahle KT. Zhang J, et al. Expert Opin Ther Targets. 2017 Aug;21(8):795-804. doi: 10.1080/14728222.2017.1351949. Epub 2017 Jul 12. Expert Opin Ther Targets. 2017. PMID: 28679296 Free PMC article. Review.

2

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. de Los Heros P, et al. Among authors: zhang j. Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478. Biochem J. 2014. PMID: 24393035 Free PMC article.

3

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. Alessi DR, et al. Among authors: zhang j. Sci Signal. 2014 Jul 15;7(334):re3. doi: 10.1126/scisignal.2005365. Sci Signal. 2014. PMID: 25028718 Review.

4

WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.

Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. Friedel P, et al. Among authors: zhang j. Sci Signal. 2015 Jun 30;8(383):ra65. doi: 10.1126/scisignal.aaa0354. Sci Signal. 2015. PMID: 26126716

5

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.

Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Kahle KT, et al. Among authors: zhang j. Sci Signal. 2016 Mar 29;9(421):ra32. doi: 10.1126/scisignal.aad0163. Sci Signal. 2016. PMID: 27025876 Free PMC article.

6

Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter.

Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Kahle KT, et al. Among authors: zhang j. Sci Signal. 2016 Aug 2;9(439):ra77. doi: 10.1126/scisignal.aae0546. Sci Signal. 2016. PMID: 27485015 Free PMC article.

7

Functional kinomics establishes a critical node of volume-sensitive cation-Cl^- cotransporter regulation in the mammalian brain.

Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Zhang J, et al. Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986. Sci Rep. 2016. PMID: 27782176 Free PMC article.

8

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition.

Zhang J, Deng X, Kahle KT. Zhang J, et al. Sci Signal. 2016 Oct 18;9(450):e3. doi: 10.1126/scisignal.aaj2227. Sci Signal. 2016. PMID: 27811182 Review.

9

WNK Kinase Signaling in Ion Homeostasis and Human Disease.

Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. Shekarabi M, et al. Among authors: zhang j. Cell Metab. 2017 Feb 7;25(2):285-299. doi: 10.1016/j.cmet.2017.01.007. Cell Metab. 2017. PMID: 28178566 Free article. Review.

10

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Karimy JK, et al. Among authors: zhang j. Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10. Nat Med. 2017. PMID: 28692063

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