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Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.
Brenner E, Schörg BF, Ahmetlić F, Wieder T, Hilke FJ, Simon N, Schroeder C, Demidov G, Riedel T, Fehrenbacher B, Schaller M, Forschner A, Eigentler T, Niessner H, Sinnberg T, Böhm KS, Hömberg N, Braumüller H, Dauch D, Zwirner S, Zender L, Sonanini D, Geishauser A, Bauer J, Eichner M, Jarick KJ, Beilhack A, Biskup S, Döcker D, Schadendorf D, Quintanilla-Martinez L, Pichler BJ, Kneilling M, Mocikat R, Röcken M. Brenner E, et al. Among authors: zender l. Nat Commun. 2020 Mar 12;11(1):1335. doi: 10.1038/s41467-020-14987-6. Nat Commun. 2020. PMID: 32165639 Free PMC article.
T-helper-1-cell cytokines drive cancer into senescence.
Braumüller H, Wieder T, Brenner E, Aßmann S, Hahn M, Alkhaled M, Schilbach K, Essmann F, Kneilling M, Griessinger C, Ranta F, Ullrich S, Mocikat R, Braungart K, Mehra T, Fehrenbacher B, Berdel J, Niessner H, Meier F, van den Broek M, Häring HU, Handgretinger R, Quintanilla-Martinez L, Fend F, Pesic M, Bauer J, Zender L, Schaller M, Schulze-Osthoff K, Röcken M. Braumüller H, et al. Among authors: zender l. Nature. 2013 Feb 21;494(7437):361-5. doi: 10.1038/nature11824. Epub 2013 Feb 3. Nature. 2013. PMID: 23376950 Free article.
Changing T-cell enigma: cancer killing or cancer control?
Wieder T, Braumüller H, Brenner E, Zender L, Röcken M. Wieder T, et al. Among authors: zender l. Cell Cycle. 2013 Oct 1;12(19):3146-53. doi: 10.4161/cc.26060. Epub 2013 Aug 26. Cell Cycle. 2013. PMID: 24013429 Free PMC article.
The administration route of tumor-antigen-specific T-helper cells differentially modulates the tumor microenvironment and senescence.
Griessinger CM, Schmid AM, Sonanini D, Schörg BF, Jarboui MA, Bukala D, Mucha N, Fehrenbacher B, Steinhilber J, Martella M, Kohlhofer U, Schaller M, Zender L, Rammensee HG, Quintanilla-Martinez L, Röcken M, Kneilling M, Pichler BJ. Griessinger CM, et al. Among authors: zender l. Carcinogenesis. 2019 Apr 29;40(2):289-302. doi: 10.1093/carcin/bgy161. Carcinogenesis. 2019. PMID: 30753335
Exploiting lipotoxicity for the treatment of liver cancer.
Rudalska R, Zender L, Dauch D. Rudalska R, et al. Among authors: zender l. Br J Cancer. 2021 Nov;125(11):1459-1461. doi: 10.1038/s41416-021-01479-7. Epub 2021 Jul 23. Br J Cancer. 2021. PMID: 34302061 Free PMC article.
Nucleoporin Nup155 is part of the p53 network in liver cancer.
Holzer K, Ori A, Cooke A, Dauch D, Drucker E, Riemenschneider P, Andres-Pons A, DiGuilio AL, Mackmull MT, Baßler J, Roessler S, Breuhahn K, Zender L, Glavy JS, Dombrowski F, Hurt E, Schirmacher P, Beck M, Singer S. Holzer K, et al. Among authors: zender l. Nat Commun. 2019 May 14;10(1):2147. doi: 10.1038/s41467-019-10133-z. Nat Commun. 2019. PMID: 31089132 Free PMC article.
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D. Rudalska R, et al. Among authors: zender l. Nat Cancer. 2021 Feb;2(2):201-217. doi: 10.1038/s43018-020-00168-3. Epub 2021 Feb 15. Nat Cancer. 2021. PMID: 35122079
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. Kang TW, et al. Among authors: zender l. Nature. 2011 Nov 9;479(7374):547-51. doi: 10.1038/nature10599. Nature. 2011. PMID: 22080947
Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer.
Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M, Bilich T, Heitmann J, Lutz M, Mattern S, Scheuermann S, Horger M, Maurer S, Walz J, Fend F, Handgretinger R, Seitz C, Weigelin B, Singer S, Salih H, Borst O, Kopp HG, Zender L. Hinterleitner C, et al. Among authors: zender l. Nat Commun. 2021 Dec 1;12(1):7005. doi: 10.1038/s41467-021-27303-7. Nat Commun. 2021. PMID: 34853305 Free PMC article.
183 results