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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
Cotman AE, Durcik M, Benedetto Tiz D, Fulgheri F, Secci D, Sterle M, Možina Š, Skok Ž, Zidar N, Zega A, Ilaš J, Peterlin Mašič L, Tomašič T, Hughes D, Huseby DL, Cao S, Garoff L, Berruga Fernández T, Giachou P, Crone L, Simoff I, Svensson R, Birnir B, Korol SV, Jin Z, Vicente F, Ramos MC, de la Cruz M, Glinghammar B, Lenhammar L, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Janssen GV, Sterk GJ, Kikelj D. Cotman AE, et al. Among authors: zega a. J Med Chem. 2023 Jan 26;66(2):1380-1425. doi: 10.1021/acs.jmedchem.2c01597. Epub 2023 Jan 12. J Med Chem. 2023. PMID: 36634346 Free PMC article.
Thrombin inhibitors built on an azaphenylalanine scaffold.
Zega A, Mlinsek G, Solmajer T, Trampus-Bakija A, Stegnar M, Urleb U. Zega A, et al. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1563-7. doi: 10.1016/j.bmcl.2003.12.083. Bioorg Med Chem Lett. 2004. PMID: 15006404
5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases.
Tomasić T, Zidar N, Kovac A, Turk S, Simcic M, Blanot D, Müller-Premru M, Filipic M, Grdadolnik SG, Zega A, Anderluh M, Gobec S, Kikelj D, Peterlin Masic L. Tomasić T, et al. Among authors: zega a. ChemMedChem. 2010 Feb 1;5(2):286-95. doi: 10.1002/cmdc.200900449. ChemMedChem. 2010. PMID: 20024979
Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.
Sosič I, Barreteau H, Simčič M, Sink R, Cesar J, Zega A, Grdadolnik SG, Contreras-Martel C, Dessen A, Amoroso A, Joris B, Blanot D, Gobec S. Sosič I, et al. Among authors: zega a. Eur J Med Chem. 2011 Jul;46(7):2880-94. doi: 10.1016/j.ejmech.2011.04.011. Epub 2011 Apr 9. Eur J Med Chem. 2011. PMID: 21524830 Free article.
65 results