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Short-term exposure to air pollution (PM2.5) induces hypothalamic inflammation, and long-term leads to leptin resistance and obesity via Tlr4/Ikbke in mice.
Campolim CM, Weissmann L, Ferreira CKO, Zordão OP, Dornellas APS, de Castro G, Zanotto TM, Boico VF, Quaresma PGF, Lima RPA, Donato J Jr, Veras MM, Saldiva PHN, Kim YB, Prada PO. Campolim CM, et al. Among authors: zanotto tm. Sci Rep. 2020 Jun 23;10(1):10160. doi: 10.1038/s41598-020-67040-3. Sci Rep. 2020. PMID: 32576879 Free PMC article.
Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis.
Quaresma PG, Weissmann L, Zanotto TM, Santos AC, de Matos AH, Furigo IC, Simabuco FM, Donato J Jr, Bittencourt JC, Lopes-Cendes I, Prada PO. Quaresma PG, et al. Among authors: zanotto tm. Int J Obes (Lond). 2017 Feb;41(2):268-278. doi: 10.1038/ijo.2016.174. Epub 2016 Oct 13. Int J Obes (Lond). 2017. PMID: 27733761
Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report.
Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O. Cable J, et al. Among authors: zanotto tm. Ann N Y Acad Sci. 2023 May;1523(1):24-37. doi: 10.1111/nyas.14974. Epub 2023 Mar 18. Ann N Y Acad Sci. 2023. PMID: 36961472 Free PMC article.