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KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target.
Wei Y, Ren X, Galbo PM Jr, Moerdler S, Wang H, Sica RA, Etemad-Gilbertson B, Shi L, Zhu L, Tang X, Lin Q, Peng M, Guan F, Zheng D, Chinai JM, Zang X. Wei Y, et al. Among authors: zang x. Sci Immunol. 2021 Jul 9;6(61):eabf9792. doi: 10.1126/sciimmunol.abf9792. Sci Immunol. 2021. PMID: 34244312 Free PMC article.
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
Zhao R, Chinai JM, Buhl S, Scandiuzzi L, Ray A, Jeon H, Ohaegbulam KC, Ghosh K, Zhao A, Scharff MD, Zang X. Zhao R, et al. Among authors: zang x. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9879-84. doi: 10.1073/pnas.1303524110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716685 Free PMC article.
Structure and cancer immunotherapy of the B7 family member B7x.
Jeon H, Vigdorovich V, Garrett-Thomson SC, Janakiram M, Ramagopal UA, Abadi YM, Lee JS, Scandiuzzi L, Ohaegbulam KC, Chinai JM, Zhao R, Yao Y, Mao Y, Sparano JA, Almo SC, Zang X. Jeon H, et al. Among authors: zang x. Cell Rep. 2014 Nov 6;9(3):1089-98. doi: 10.1016/j.celrep.2014.09.053. Epub 2014 Oct 30. Cell Rep. 2014. PMID: 25437562 Free PMC article.
New immunotherapies targeting the PD-1 pathway.
Chinai JM, Janakiram M, Chen F, Chen W, Kaplan M, Zang X. Chinai JM, et al. Among authors: zang x. Trends Pharmacol Sci. 2015 Sep;36(9):587-95. doi: 10.1016/j.tips.2015.06.005. Epub 2015 Jul 7. Trends Pharmacol Sci. 2015. PMID: 26162965 Free PMC article. Review.
1,121 results