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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Nordström E, Eriksson F, Sigvardson J, Johannesson M, Kasrayan A, Jones-Kostalla M, Appelkvist P, Söderberg L, Nygren P, Blom M, Rachalski A, Nordenankar K, Zachrisson O, Amandius E, Osswald G, Moge M, Ingelsson M, Bergström J, Lannfelt L, Möller C, Giorgetti M, Fälting J. Nordström E, et al. Among authors: zachrisson o. Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1. Neurobiol Dis. 2021. PMID: 34737044 Free article.
Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease.
Johannesson M, Sahlin C, Söderberg L, Basun H, Fälting J, Möller C, Zachrisson O, Sunnemark D, Svensson A, Odergren T, Lannfelt L. Johannesson M, et al. Among authors: zachrisson o. Mol Cell Neurosci. 2021 Jul;114:103641. doi: 10.1016/j.mcn.2021.103641. Epub 2021 Jun 4. Mol Cell Neurosci. 2021. PMID: 34091073
In vivo imaging of alpha-synuclein with antibody-based PET.
Roshanbin S, Xiong M, Hultqvist G, Söderberg L, Zachrisson O, Meier S, Ekmark-Lewén S, Bergström J, Ingelsson M, Sehlin D, Syvänen S. Roshanbin S, et al. Among authors: zachrisson o. Neuropharmacology. 2022 May 1;208:108985. doi: 10.1016/j.neuropharm.2022.108985. Epub 2022 Feb 8. Neuropharmacology. 2022. PMID: 35149134 Free article.
PACAP promotes neural stem cell proliferation in adult mouse brain.
Mercer A, Rönnholm H, Holmberg J, Lundh H, Heidrich J, Zachrisson O, Ossoinak A, Frisén J, Patrone C. Mercer A, et al. Among authors: zachrisson o. J Neurosci Res. 2004 Apr 15;76(2):205-15. doi: 10.1002/jnr.20038. J Neurosci Res. 2004. PMID: 15048918
Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients.
Paul G, Zachrisson O, Varrone A, Almqvist P, Jerling M, Lind G, Rehncrona S, Linderoth B, Bjartmarz H, Shafer LL, Coffey R, Svensson M, Mercer KJ, Forsberg A, Halldin C, Svenningsson P, Widner H, Frisén J, Pålhagen S, Haegerstrand A. Paul G, et al. Among authors: zachrisson o. J Clin Invest. 2015 Mar 2;125(3):1339-46. doi: 10.1172/JCI79635. Epub 2015 Feb 17. J Clin Invest. 2015. PMID: 25689258 Free PMC article. Clinical Trial.
Intracerebroventricular delivery of vascular endothelial growth factor in patients with amyotrophic lateral sclerosis, a phase I study.
Van Damme P, Tilkin P, Mercer KJ, Terryn J, D'Hondt A, Herne N, Tousseyn T, Claeys KG, Thal DR, Zachrisson O, Almqvist P, Nuttin B, Jerling M, Bernadotte F, Haegerstrand A, Robberecht W. Van Damme P, et al. Among authors: zachrisson o. Brain Commun. 2020 Sep 29;2(2):fcaa160. doi: 10.1093/braincomms/fcaa160. eCollection 2020. Brain Commun. 2020. PMID: 33977260 Free PMC article.
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