Zacharias M - Search Results

1

Altered Hinge Conformations in APP Transmembrane Helix Mutants May Affect Enzyme-Substrate Interactions of γ-Secretase.

Silber M, Hitzenberger M, Zacharias M, Muhle-Goll C. Silber M, et al. Among authors: zacharias m. ACS Chem Neurosci. 2020 Dec 16;11(24):4426-4433. doi: 10.1021/acschemneuro.0c00640. Epub 2020 Nov 24. ACS Chem Neurosci. 2020. PMID: 33232115

2

Structural Modeling of γ-Secretase Aβ _n Complex Formation and Substrate Processing.

Hitzenberger M, Zacharias M. Hitzenberger M, et al. Among authors: zacharias m. ACS Chem Neurosci. 2019 Mar 20;10(3):1826-1840. doi: 10.1021/acschemneuro.8b00725. Epub 2019 Jan 30. ACS Chem Neurosci. 2019. PMID: 30638370

3

γ-Secretase Studied by Atomistic Molecular Dynamics Simulations: Global Dynamics, Enzyme Activation, Water Distribution and Lipid Binding.

Hitzenberger M, Zacharias M. Hitzenberger M, et al. Among authors: zacharias m. Front Chem. 2019 Jan 4;6:640. doi: 10.3389/fchem.2018.00640. eCollection 2018. Front Chem. 2019. PMID: 30662893 Free PMC article.

4

Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators.

Petit D, Hitzenberger M, Lismont S, Zoltowska KM, Ryan NS, Mercken M, Bischoff F, Zacharias M, Chávez-Gutiérrez L. Petit D, et al. Among authors: zacharias m. EMBO J. 2019 Jun 17;38(12):e101494. doi: 10.15252/embj.2019101494. Epub 2019 May 20. EMBO J. 2019. PMID: 31109937 Free PMC article.

5

Uncovering the Binding Mode of γ -Secretase Inhibitors.

Hitzenberger M, Zacharias M. Hitzenberger M, et al. Among authors: zacharias m. ACS Chem Neurosci. 2019 Aug 21;10(8):3398-3403. doi: 10.1021/acschemneuro.9b00272. Epub 2019 Jun 25. ACS Chem Neurosci. 2019. PMID: 31244051

6

The dynamics of γ-secretase and its substrates.

Hitzenberger M, Götz A, Menig S, Brunschweiger B, Zacharias M, Scharnagl C. Hitzenberger M, et al. Among authors: zacharias m. Semin Cell Dev Biol. 2020 Sep;105:86-101. doi: 10.1016/j.semcdb.2020.04.008. Epub 2020 May 16. Semin Cell Dev Biol. 2020. PMID: 32423851 Review.

7

CHARMM-GUI supports the Amber force fields.

Lee J, Hitzenberger M, Rieger M, Kern NR, Zacharias M, Im W. Lee J, et al. Among authors: zacharias m. J Chem Phys. 2020 Jul 21;153(3):035103. doi: 10.1063/5.0012280. J Chem Phys. 2020. PMID: 32716185

8

How Mutations Perturb γ-Secretase Active Site Studied by Free Energy Simulations.

Chen SY, Zacharias M. Chen SY, et al. Among authors: zacharias m. ACS Chem Neurosci. 2020 Oct 21;11(20):3321-3332. doi: 10.1021/acschemneuro.0c00440. Epub 2020 Oct 6. ACS Chem Neurosci. 2020. PMID: 32960571

9

Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains.

Rottenaicher GJ, Weber B, Rührnößl F, Kazman P, Absmeier RM, Hitzenberger M, Zacharias M, Buchner J. Rottenaicher GJ, et al. Among authors: zacharias m. J Biol Chem. 2021 Jan-Jun;296:100334. doi: 10.1016/j.jbc.2021.100334. Epub 2021 Jan 26. J Biol Chem. 2021. PMID: 33508322 Free PMC article.

10

Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding.

Heerde T, Rennegarbe M, Biedermann A, Savran D, Pfeiffer PB, Hitzenberger M, Baur J, Puscalau-Girtu I, Zacharias M, Schwierz N, Haupt C, Schmidt M, Fändrich M. Heerde T, et al. Among authors: zacharias m. Nat Commun. 2022 Jan 10;13(1):85. doi: 10.1038/s41467-021-27688-5. Nat Commun. 2022. PMID: 35013242 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

537 results

Search Page