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Interfacial inhibitors.
Pommier Y, Kiselev E, Marchand C. Pommier Y, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3961-5. doi: 10.1016/j.bmcl.2015.07.032. Epub 2015 Jul 18. Bioorg Med Chem Lett. 2015. PMID: 26235949 Free PMC article. Review.
Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain.
Cuzzucoli Crucitti G, Métifiot M, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Esposito F, Corona A, Cadeddu M, Marchand C, Pommier Y, Tramontano E, Costi R, Di Santo R. Cuzzucoli Crucitti G, et al. J Med Chem. 2015 Feb 26;58(4):1915-28. doi: 10.1021/jm501799k. Epub 2015 Feb 11. J Med Chem. 2015. PMID: 25629256 Free PMC article.
6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-5-hexenoic acids as dual inhibitors of recombinant HIV-1 integrase and ribonuclease H, synthesized by a parallel synthesis approach.
Costi R, Métifiot M, Esposito F, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Zinzula L, Novellino E, Pommier Y, Tramontano E, Marchand C, Di Santo R. Costi R, et al. J Med Chem. 2013 Nov 14;56(21):8588-98. doi: 10.1021/jm401040b. Epub 2013 Nov 5. J Med Chem. 2013. PMID: 24124919 Free PMC article.
MK-0536 inhibits HIV-1 integrases resistant to raltegravir.
Métifiot M, Johnson B, Smith S, Zhao XZ, Marchand C, Burke T, Hughes S, Pommier Y. Métifiot M, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5127-33. doi: 10.1128/AAC.05288-11. Epub 2011 Aug 29. Antimicrob Agents Chemother. 2011. PMID: 21876054 Free PMC article.