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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity.
Fang L, Hao Y, Yu H, Gu X, Peng Q, Zhuo H, Li Y, Liu Z, Wang J, Chen Y, Zhang J, Tian H, Gao Y, Gao R, Teng H, Shan Z, Zhu J, Li Z, Liu Y, Zhang Y, Yu F, Lin Z, Hao Y, Ge X, Yuan J, Hu HG, Ma Y, Qin HL, Wang P. Fang L, et al. Among authors: yuan j. Cancer Cell. 2023 Jun 12;41(6):1118-1133.e12. doi: 10.1016/j.ccell.2023.05.005. Epub 2023 Jun 1. Cancer Cell. 2023. PMID: 37267951 Free article.
Synergistic anticancer effect by targeting CDK2 and EGFR-ERK signaling.
Wu J, Chen Y, Li R, Guan Y, Chen M, Yin H, Yang X, Jin M, Huang B, Ding X, Yang J, Wang Z, He Y, Wang Q, Luo J, Wang P, Mao Z, Huen MSY, Lou Z, Yuan J, Gong F. Wu J, et al. Among authors: yuan j. J Cell Biol. 2024 Jan 1;223(1):e202203005. doi: 10.1083/jcb.202203005. Epub 2023 Nov 13. J Cell Biol. 2024. PMID: 37955924
Metabolic regulation of homologous recombination repair by MRE11 lactylation.
Chen Y, Wu J, Zhai L, Zhang T, Yin H, Gao H, Zhao F, Wang Z, Yang X, Jin M, Huang B, Ding X, Li R, Yang J, He Y, Wang Q, Wang W, Kloeber JA, Li Y, Hao B, Zhang Y, Wang J, Tan M, Li K, Wang P, Lou Z, Yuan J. Chen Y, et al. Among authors: yuan j. Cell. 2024 Jan 18;187(2):294-311.e21. doi: 10.1016/j.cell.2023.11.022. Epub 2023 Dec 20. Cell. 2024. PMID: 38128537
Deubiquitination and Activation of AMPK by USP10.
Deng M, Yang X, Qin B, Liu T, Zhang H, Guo W, Lee SB, Kim JJ, Yuan J, Pei H, Wang L, Lou Z. Deng M, et al. Among authors: yuan j. Mol Cell. 2016 Feb 18;61(4):614-624. doi: 10.1016/j.molcel.2016.01.010. Epub 2016 Feb 11. Mol Cell. 2016. PMID: 26876938 Free PMC article.
DUB3/KLF4 combats tumor growth and chemoresistance in hepatocellular carcinoma.
Jia X, Li L, Wang F, Xue Y, Wu T, Jia Q, Li Y, Wu C, Chen Y, Wu J, Su Y, Wang X, Zhuang T, Dong X, Ling J, Yuan J, Li Q. Jia X, et al. Among authors: yuan j. Cell Death Discov. 2022 Apr 5;8(1):166. doi: 10.1038/s41420-022-00988-5. Cell Death Discov. 2022. PMID: 35383144 Free PMC article.
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.
Zeng X, Zhao F, Cui G, Zhang Y, Deshpande RA, Chen Y, Deng M, Kloeber JA, Shi Y, Zhou Q, Zhang C, Hou J, Kim W, Tu X, Yan Y, Xu Z, Chen L, Gao H, Guo G, Liu J, Zhu Q, Cao Y, Huang J, Wu Z, Zhu S, Yin P, Luo K, Mer G, Paull TT, Yuan J, Tao K, Lou Z. Zeng X, et al. Among authors: yuan j. Nat Cancer. 2022 Sep;3(9):1088-1104. doi: 10.1038/s43018-022-00429-3. Epub 2022 Sep 22. Nat Cancer. 2022. PMID: 36138131
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