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Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.
Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Abdelsamed HA, et al. Among authors: youngblood b. Nat Immunol. 2020 May;21(5):578-587. doi: 10.1038/s41590-020-0633-5. Epub 2020 Mar 30. Nat Immunol. 2020. PMID: 32231298 Free PMC article.
Defining the Molecular Hallmarks of T-Cell Memory.
Zebley CC, Akondy RS, Youngblood BA, Kissick HT. Zebley CC, et al. Cold Spring Harb Perspect Biol. 2022 Mar 1;14(3):a037804. doi: 10.1101/cshperspect.a037804. Cold Spring Harb Perspect Biol. 2022. PMID: 34127444 Free PMC article. Review.
BATF targets T cell exhaustion for termination.
Boi SK, Lan X, Youngblood B. Boi SK, et al. Among authors: youngblood b. Nat Immunol. 2021 Aug;22(8):936-938. doi: 10.1038/s41590-021-00978-2. Nat Immunol. 2021. PMID: 34282328 Free PMC article.
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.
Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Prinzing B, et al. Among authors: youngblood b. Sci Transl Med. 2021 Nov 17;13(620):eabh0272. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34788079 Free PMC article.
Improving antitumor T cells.
Zebley CC, Youngblood B. Zebley CC, et al. Among authors: youngblood b. Science. 2022 Nov 11;378(6620):598. doi: 10.1126/science.adf0546. Epub 2022 Nov 10. Science. 2022. PMID: 36356156
151 results