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Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. Kwon JJ, et al. Among authors: young lc. Nature. 2022 Sep;609(7926):408-415. doi: 10.1038/s41586-022-04928-2. Epub 2022 Jul 13. Nature. 2022. PMID: 35831509 Free PMC article.
MRAS: A Close but Understudied Member of the RAS Family.
Young LC, Rodriguez-Viciana P. Young LC, et al. Cold Spring Harb Perspect Med. 2018 Dec 3;8(12):a033621. doi: 10.1101/cshperspect.a033621. Cold Spring Harb Perspect Med. 2018. PMID: 29311130 Free PMC article. Review.
Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization.
Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. Young LC, et al. Proc Natl Acad Sci U S A. 2023 Jan 31;120(5):e2208960120. doi: 10.1073/pnas.2208960120. Epub 2023 Jan 23. Proc Natl Acad Sci U S A. 2023. PMID: 36689660 Free PMC article.
SHOC2 complex-driven RAF dimerization selectively contributes to ERK pathway dynamics.
Boned Del Río I, Young LC, Sari S, Jones GG, Ringham-Terry B, Hartig N, Rejnowicz E, Lei W, Bhamra A, Surinova S, Rodriguez-Viciana P. Boned Del Río I, et al. Among authors: young lc. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13330-13339. doi: 10.1073/pnas.1902658116. Epub 2019 Jun 18. Proc Natl Acad Sci U S A. 2019. PMID: 31213532 Free PMC article.
Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF complex.
Roehrig AE, Klupsch K, Oses-Prieto JA, Chaib S, Henderson S, Emmett W, Young LC, Surinova S, Blees A, Pfeiffer A, Tijani M, Brunk F, Hartig N, Muñoz-Alegre M, Hergovich A, Jennings BH, Burlingame AL, Rodriguez-Viciana P. Roehrig AE, et al. Among authors: young lc. PLoS One. 2021 Aug 23;16(8):e0254697. doi: 10.1371/journal.pone.0254697. eCollection 2021. PLoS One. 2021. PMID: 34424918 Free PMC article.
Ensuring access to innovative therapies for children, adolescents, and young adults across Canada: The single patient study experience.
Revon-Riviere G, Young LC, Stephenson EA, Brodeur-Robb K, Cohen-Gogo S, Deyell R, Lacaze-Masmonteil T, Palmer A, Parekh RS, Whitlock JA, Morgenstern DA. Revon-Riviere G, et al. Among authors: young lc. Paediatr Child Health. 2023 Apr 20;28(7):399-403. doi: 10.1093/pch/pxac122. eCollection 2023 Nov. Paediatr Child Health. 2023. PMID: 37885599 Free PMC article. Review.
120 results