Young JE - Search Results

1

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides.

Frankowski H, Yeboah F, Berry BJ, Kinoshita C, Lee M, Evitts K, Davis J, Kinoshita Y, Morrison RS, Young JE. Frankowski H, et al. Among authors: young je. Int J Mol Sci. 2021 Mar 3;22(5):2526. doi: 10.3390/ijms22052526. Int J Mol Sci. 2021. PMID: 33802405 Free PMC article.

2

Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.

Young JE, Garden GA, Martinez RA, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, Taylor JP, La Spada AR. Young JE, et al. J Neurosci. 2009 Feb 18;29(7):1987-97. doi: 10.1523/JNEUROSCI.4072-08.2009. J Neurosci. 2009. PMID: 19228953 Free PMC article.

3

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Cortes CJ, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. Cortes CJ, et al. Among authors: young je. Nat Neurosci. 2014 Sep;17(9):1180-9. doi: 10.1038/nn.3787. Epub 2014 Aug 10. Nat Neurosci. 2014. PMID: 25108912 Free PMC article.

4

Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds.

Rose SE, Frankowski H, Knupp A, Berry BJ, Martinez R, Dinh SQ, Bruner LT, Willis SL, Crane PK, Larson EB, Grabowski T, Darvas M, Keene CD, Young JE. Rose SE, et al. Among authors: young je. J Neuropathol Exp Neurol. 2018 May 1;77(5):353-360. doi: 10.1093/jnen/nly013. J Neuropathol Exp Neurol. 2018. PMID: 29474672 Free PMC article.

5

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB. Young JE, et al. Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1. Stem Cell Reports. 2018. PMID: 29503090 Free PMC article.

6

Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes.

Fong LK, Yang MM, Dos Santos Chaves R, Reyna SM, Langness VF, Woodruff G, Roberts EA, Young JE, Goldstein LSB. Fong LK, et al. Among authors: young je. J Biol Chem. 2018 Jul 20;293(29):11341-11357. doi: 10.1074/jbc.RA117.000441. Epub 2018 Jun 1. J Biol Chem. 2018. PMID: 29858247 Free PMC article.

7

Advances and Current Challenges Associated with the Use of Human Induced Pluripotent Stem Cells in Modeling Neurodegenerative Disease.

Berry BJ, Smith AST, Young JE, Mack DL. Berry BJ, et al. Among authors: young je. Cells Tissues Organs. 2018;205(5-6):331-349. doi: 10.1159/000493018. Epub 2018 Oct 9. Cells Tissues Organs. 2018. PMID: 30300891 Free article. Review.

8

Alternative splicing in a presenilin 2 variant associated with Alzheimer disease.

Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S. Braggin JE, et al. Among authors: young je. Ann Clin Transl Neurol. 2019 Mar 10;6(4):762-777. doi: 10.1002/acn3.755. eCollection 2019 Apr. Ann Clin Transl Neurol. 2019. PMID: 31020001 Free PMC article.

9

Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells.

Almenar-Queralt A, Merkurjev D, Kim HS, Navarro M, Ma Q, Chaves RS, Allegue C, Driscoll SP, Chen AG, Kohlnhofer B, Fong LK, Woodruff G, Mackintosh C, Bohaciakova D, Hruska-Plochan M, Tadokoro T, Young JE, El Hajj N, Dittrich M, Marsala M, Goldstein LSB, Garcia-Bassets I. Almenar-Queralt A, et al. Among authors: young je. Nat Genet. 2019 Dec;51(12):1691-1701. doi: 10.1038/s41588-019-0526-4. Epub 2019 Nov 18. Nat Genet. 2019. PMID: 31740836 Free PMC article.

10

The application of in vitro-derived human neurons in neurodegenerative disease modeling.

D'Souza GX, Rose SE, Knupp A, Nicholson DA, Keene CD, Young JE. D'Souza GX, et al. Among authors: young je. J Neurosci Res. 2021 Jan;99(1):124-140. doi: 10.1002/jnr.24615. Epub 2020 Mar 13. J Neurosci Res. 2021. PMID: 32170790 Free PMC article. Review.

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