Yoshimoto FK - Search Results

1

Chemical synthesis of 7α-hydroxypregnenolone, a neuroactive steroid that stimulates locomotor activity.

Yoshimoto FK, Arman HD, Griffith WP, Yan F, Wherritt DJ. Yoshimoto FK, et al. Steroids. 2017 Dec;128:50-57. doi: 10.1016/j.steroids.2017.10.004. Epub 2017 Oct 20. Steroids. 2017. PMID: 29061488

2

Chemical synthesis of 7-oxygenated 12α-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12α-hydroxylase enzyme implicated in cardiovascular health and obesity.

Offei SD, Arman HD, Baig MO, Chavez LS, Paladini CA, Yoshimoto FK. Offei SD, et al. Among authors: yoshimoto fk. Steroids. 2018 Dec;140:185-195. doi: 10.1016/j.steroids.2018.10.010. Epub 2018 Nov 3. Steroids. 2018. PMID: 30399365 Free PMC article.

3

Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption.

Offei SD, Arman HD, Yoshimoto FK. Offei SD, et al. Among authors: yoshimoto fk. Steroids. 2019 Nov;151:108449. doi: 10.1016/j.steroids.2019.108449. Epub 2019 Jul 11. Steroids. 2019. PMID: 31302111

4

Synthesis of [3,3-²H₂]-Dihydroartemisinic Acid to Measure the Rate of Nonenzymatic Conversion of Dihydroartemisinic Acid to Artemisinin.

Varela K, Arman HD, Yoshimoto FK. Varela K, et al. Among authors: yoshimoto fk. J Nat Prod. 2020 Jan 24;83(1):66-78. doi: 10.1021/acs.jnatprod.9b00686. Epub 2019 Dec 20. J Nat Prod. 2020. PMID: 31859509 Free PMC article.

5

Synthesis of [15,15,15-²H₃]-Dihydroartemisinic Acid and Isotope Studies Support a Mixed Mechanism in the Endoperoxide Formation to Artemisinin.

Varela K, Arman HD, Yoshimoto FK. Varela K, et al. Among authors: yoshimoto fk. J Nat Prod. 2021 Jul 23;84(7):1967-1984. doi: 10.1021/acs.jnatprod.1c00246. Epub 2021 Jun 17. J Nat Prod. 2021. PMID: 34137611

6

A synthesis of a rationally designed inhibitor of cytochrome P450 8B1, a therapeutic target to treat obesity.

Chung E, Offei SD, Aondo Jia UT, Estevez J, Perez Y, Arman HD, Yoshimoto FK. Chung E, et al. Among authors: yoshimoto fk. Steroids. 2022 Feb;178:108952. doi: 10.1016/j.steroids.2021.108952. Epub 2021 Dec 27. Steroids. 2022. PMID: 34968450 Free PMC article.

7

Autoxidation of a C2-Olefinated Dihydroartemisinic Acid Analogue to Form an Aromatic Ring: Application to Serrulatene Biosynthesis.

Varela K, Al Mahmud H, Arman HD, Martinez LR, Wakeman CA, Yoshimoto FK. Varela K, et al. Among authors: yoshimoto fk. J Nat Prod. 2022 Apr 22;85(4):951-962. doi: 10.1021/acs.jnatprod.1c01101. Epub 2022 Mar 31. J Nat Prod. 2022. PMID: 35357832 Free PMC article. Review.

8

Copper oxidation chemistry using a 19-iminopyridine-bearing steroidal ligand: (i) C5-C6 olefin difunctionalization and (ii) C1β-hydroxylation/C19-peroxidation.

Offei SD, Arman HD, Yoshimoto FK. Offei SD, et al. Among authors: yoshimoto fk. Steroids. 2022 Oct;186:109088. doi: 10.1016/j.steroids.2022.109088. Epub 2022 Jul 11. Steroids. 2022. PMID: 35835204

9

Synthesis of menarandroside A from dehydroepiandrosterone.

Offei SD, Arman HD, Yoshimoto FK. Offei SD, et al. Among authors: yoshimoto fk. Org Biomol Chem. 2023 Apr 12;21(15):3172-3176. doi: 10.1039/d3ob00054k. Org Biomol Chem. 2023. PMID: 36950968

10

Inhibition of Cysteine Proteases via Thiol-Michael Addition Explains the Anti-SARS-CoV-2 and Bioactive Properties of Arteannuin B.

Varela K, Arman HD, Berger MS, Sponsel VM, Lin CA, Yoshimoto FK. Varela K, et al. Among authors: yoshimoto fk. J Nat Prod. 2023 Jul 28;86(7):1654-1666. doi: 10.1021/acs.jnatprod.2c01146. Epub 2023 Jul 17. J Nat Prod. 2023. PMID: 37458412

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