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Showing results for lucarini x
Search for Yocarini X instead (1 results)
Disruption of the microbiota-gut-brain axis is a defining characteristic of the α-Gal A (-/0) mouse model of Fabry disease.
Delprete C, Rimondini Giorgini R, Lucarini E, Bastiaanssen TFS, Scicchitano D, Interino N, Formaggio F, Uhlig F, Ghelardini C, Hyland NP, Cryan JF, Liguori R, Candela M, Fiori J, Turroni S, Di Cesare Mannelli L, Caprini M. Delprete C, et al. Gut Microbes. 2023 Dec;15(2):2256045. doi: 10.1080/19490976.2023.2256045. Gut Microbes. 2023. PMID: 37712629 Free PMC article.
Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in alpha-galactosidase A (alpha-Gal A) activity. ...
Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in alpha-galactosidase A (alpha-Gal A) activity. ...
Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.
Angeli A, di Cesare Mannelli L, Lucarini E, Peat TS, Ghelardini C, Supuran CT. Angeli A, et al. Eur J Med Chem. 2018 Jun 25;154:210-219. doi: 10.1016/j.ejmech.2018.05.026. Epub 2018 May 19. Eur J Med Chem. 2018. PMID: 29803994
These selenides showed on the other hand moderate inhibition against the cytosolic isoforms hCA I and transmembrane hCA IX. X-ray crystallographic data of two derivatives bound to hCA II allowed us to rationalize the excellent inhibitory data. ...
These selenides showed on the other hand moderate inhibition against the cytosolic isoforms hCA I and transmembrane hCA IX. X-ray cry …
Coronary microvascular disease in hypertensives.
Lucarini AR, Picano E, Salvetti A. Lucarini AR, et al. Clin Exp Hypertens A. 1992;14(1-2):55-66. doi: 10.3109/10641969209036171. Clin Exp Hypertens A. 1992. PMID: 1541047 Review.
To address this issue, we used dipyridamole- echocardiography test, which causes ischemic-like ST segment depression with no detectable changes in left ventricular function in different subsets of patients with microvascular disease (Syndrome X; Hypertrophic cardiomyopathy …
To address this issue, we used dipyridamole- echocardiography test, which causes ischemic-like ST segment depression with no detectable chan …
1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads.
Ferraroni M, Lucarini L, Masini E, Korsakov M, Scozzafava A, Supuran CT, Krasavin M. Ferraroni M, et al. Bioorg Med Chem. 2017 Sep 1;25(17):4560-4565. doi: 10.1016/j.bmc.2017.06.054. Epub 2017 Jul 11. Bioorg Med Chem. 2017. PMID: 28728897
Finally, the reasons for unusually high potency of these compounds became understood from their high-resolution X-ray crystallography structures. These data significantly expand our understanding of heterocycle-based primary sulfonamides, many of which have recently emerge …
Finally, the reasons for unusually high potency of these compounds became understood from their high-resolution X-ray crystallography …
Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain.
Akgül Ö, Lucarini E, Mannelli LDC, Ghelardini C, D'Ambrosio K, Buonanno M, Monti SM, De Simone G, Angeli A, Supuran CT, Carta F. Akgül Ö, et al. Eur J Med Chem. 2022 Jan 5;227:113956. doi: 10.1016/j.ejmech.2021.113956. Epub 2021 Oct 29. Eur J Med Chem. 2022. PMID: 34731762
The binding mode of 11 within the hCA VII active site was deciphered by means of X-ray crystallography and revealed the sultam moiety being exposed to the rim of the active site. ...
The binding mode of 11 within the hCA VII active site was deciphered by means of X-ray crystallography and revealed the sultam moiety …
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
Vannozzi G, Vullo D, Angeli A, Ferraroni M, Combs J, Lomelino C, Andring J, Mckenna R, Bartolucci G, Pallecchi M, Lucarini L, Sgambellone S, Masini E, Carta F, Supuran CT. Vannozzi G, et al. J Med Chem. 2022 Jan 13;65(1):824-837. doi: 10.1021/acs.jmedchem.1c01906. Epub 2021 Dec 27. J Med Chem. 2022. PMID: 34958217
In addition, the binding modes of 7c, 11f, and 11g were assessed by means of X-ray crystallography....
In addition, the binding modes of 7c, 11f, and 11g were assessed by means of X-ray crystallography....
Rough basin boundaries in high dimension: Can we classify them experimentally?
Bódai T, Lucarini V. Bódai T, et al. Chaos. 2020 Oct;30(10):103105. doi: 10.1063/5.0002577. Chaos. 2020. PMID: 33138466
We show in 2D noninvertible- and 3D invertible-minimal models, that, formally, it cannot be matched with lambda(x). Rather, the partial dimension D(0) ((x)) that lambda(x) is associated with in the case of rough boundaries is trivially unity. Further results …
We show in 2D noninvertible- and 3D invertible-minimal models, that, formally, it cannot be matched with lambda(x). Rather, the parti …
Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action.
Fares M, Eldehna WM, Bua S, Lanzi C, Lucarini L, Masini E, Peat TS, Abdel-Aziz HA, Nocentini A, Keller PA, Supuran CT. Fares M, et al. J Med Chem. 2020 Mar 26;63(6):3317-3326. doi: 10.1021/acs.jmedchem.9b02090. Epub 2020 Feb 20. J Med Chem. 2020. PMID: 32031797
Compounds 11a-11g emerged as potent CA inhibitors against the four tested isoforms with a significant selectivity to CA II, which is implicated in glaucoma (K(i) in the range 0.36-6.9 nM). X-ray crystallographic analysis of three compounds (11a, 11d, and 11g) bound to CA I …
Compounds 11a-11g emerged as potent CA inhibitors against the four tested isoforms with a significant selectivity to CA II, which is implica …
38 results