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Population Pharmacokinetic Model Linking Plasma and Peripheral Blood Mononuclear Cell Concentrations of Efavirenz and Its Metabolite, 8-Hydroxy-Efavirenz, in HIV Patients.
Habtewold A, Aklillu E, Makonnen E, Yimer G, Bertilsson L, Burhenne J, Owen JS. Habtewold A, et al. Among authors: yimer g. Antimicrob Agents Chemother. 2017 Jul 25;61(8):e00207-17. doi: 10.1128/AAC.00207-17. Print 2017 Aug. Antimicrob Agents Chemother. 2017. PMID: 28559276 Free PMC article.
Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients.
Habtewold A, Amogne W, Makonnen E, Yimer G, Riedel KD, Ueda N, Worku A, Haefeli WE, Lindquist L, Aderaye G, Burhenne J, Aklillu E. Habtewold A, et al. Among authors: yimer g. J Antimicrob Chemother. 2011 Oct;66(10):2350-61. doi: 10.1093/jac/dkr304. Epub 2011 Aug 16. J Antimicrob Chemother. 2011. PMID: 21846671
High plasma efavirenz level and CYP2B6*6 are associated with efavirenz-based HAART-induced liver injury in the treatment of naïve HIV patients from Ethiopia: a prospective cohort study.
Yimer G, Amogne W, Habtewold A, Makonnen E, Ueda N, Suda A, Worku A, Haefeli WE, Burhenne J, Aderaye G, Lindquist L, Aklillu E. Yimer G, et al. Pharmacogenomics J. 2012 Dec;12(6):499-506. doi: 10.1038/tpj.2011.34. Epub 2011 Aug 23. Pharmacogenomics J. 2012. PMID: 21862974
Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations.
Ngaimisi E, Habtewold A, Minzi O, Makonnen E, Mugusi S, Amogne W, Yimer G, Riedel KD, Janabi M, Aderaye G, Mugusi F, Bertilsson L, Aklillu E, Burhenne J. Ngaimisi E, et al. Among authors: yimer g. PLoS One. 2013 Jul 5;8(7):e67946. doi: 10.1371/journal.pone.0067946. Print 2013. PLoS One. 2013. PMID: 23861838 Free PMC article. Clinical Trial.
Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.
Thulin P, Nordahl G, Gry M, Yimer G, Aklillu E, Makonnen E, Aderaye G, Lindquist L, Mattsson CM, Ekblom B, Antoine DJ, Park BK, Linder S, Harrill AH, Watkins PB, Glinghammar B, Schuppe-Koistinen I. Thulin P, et al. Among authors: yimer g. Liver Int. 2014 Mar;34(3):367-78. doi: 10.1111/liv.12322. Epub 2013 Oct 14. Liver Int. 2014. PMID: 24118944
CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.
Aklillu E, Odenthal-Hesse L, Bowdrey J, Habtewold A, Ngaimisi E, Yimer G, Amogne W, Mugusi S, Minzi O, Makonnen E, Janabi M, Mugusi F, Aderaye G, Hardwick R, Fu B, Viskaduraki M, Yang F, Hollox EJ. Aklillu E, et al. Among authors: yimer g. BMC Infect Dis. 2013 Nov 12;13:536. doi: 10.1186/1471-2334-13-536. BMC Infect Dis. 2013. PMID: 24219137 Free PMC article.
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