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The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Wiederhold NP, Lockhart SR, Najvar LK, Berkow EL, Jaramillo R, Olivo M, Garvey EP, Yates CM, Schotzinger RJ, Catano G, Patterson TF. Wiederhold NP, et al. Among authors: yates cm. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18. doi: 10.1128/AAC.02233-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30530603 Free PMC article.
Design and optimization of highly-selective fungal CYP51 inhibitors.
Hoekstra WJ, Garvey EP, Moore WR, Rafferty SW, Yates CM, Schotzinger RJ. Hoekstra WJ, et al. Among authors: yates cm. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3455-8. doi: 10.1016/j.bmcl.2014.05.068. Epub 2014 Jun 9. Bioorg Med Chem Lett. 2014. PMID: 24948565
Crystal Structure of the New Investigational Drug Candidate VT-1598 in Complex with Aspergillus fumigatus Sterol 14α-Demethylase Provides Insights into Its Broad-Spectrum Antifungal Activity.
Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI. Hargrove TY, et al. Among authors: yates cm. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00570-17. doi: 10.1128/AAC.00570-17. Print 2017 Jul. Antimicrob Agents Chemother. 2017. PMID: 28461309 Free PMC article.
The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis.
Wiederhold NP, Shubitz LF, Najvar LK, Jaramillo R, Olivo M, Catano G, Trinh HT, Yates CM, Schotzinger RJ, Garvey EP, Patterson TF. Wiederhold NP, et al. Among authors: yates cm. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02258-17. doi: 10.1128/AAC.02258-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29437615 Free PMC article.
VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice.
Break TJ, Desai JV, Healey KR, Natarajan M, Ferre EMN, Henderson C, Zelazny A, Siebenlist U, Yates CM, Cohen OJ, Schotzinger RJ, Perlin DS, Garvey EP, Lionakis MS. Break TJ, et al. Among authors: yates cm. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094. doi: 10.1093/jac/dky170. J Antimicrob Chemother. 2018. PMID: 29788070 Free PMC article.
In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.
Nishimoto AT, Wiederhold NP, Flowers SA, Zhang Q, Kelly SL, Morschhäuser J, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD. Nishimoto AT, et al. Among authors: yates cm. Antimicrob Agents Chemother. 2019 May 24;63(6):e00341-19. doi: 10.1128/AAC.00341-19. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30910896 Free PMC article.
157 results