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An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models.
Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa JI, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T. Urano E, et al. Among authors: yasutomi y. Sci Transl Med. 2023 Aug 30;15(711):eadi2623. doi: 10.1126/scitranslmed.adi2623. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647387
COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions.
Urano E, Okamura T, Ono C, Ueno S, Nagata S, Kamada H, Higuchi M, Furukawa M, Kamitani W, Matsuura Y, Kawaoka Y, Yasutomi Y. Urano E, et al. Among authors: yasutomi y. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104847118. doi: 10.1073/pnas.2104847118. Proc Natl Acad Sci U S A. 2021. PMID: 34625475 Free PMC article.
Vaccination with Intradermal Bacillus Calmette-Guérin Provides Robust Protection against Extrapulmonary Tuberculosis but Not Pulmonary Infection in Cynomolgus Macaques.
Tsujimura Y, Shiogama Y, Soma S, Okamura T, Takano J, Urano E, Murakata Y, Kawano A, Yamakawa N, Asaka MN, Matsuo K, Yasutomi Y. Tsujimura Y, et al. Among authors: yasutomi y. J Immunol. 2020 Dec 1;205(11):3023-3036. doi: 10.4049/jimmunol.2000386. Epub 2020 Oct 23. J Immunol. 2020. PMID: 33097574
Quintuple deglycosylation mutant of simian immunodeficiency virus SIVmac239 in rhesus macaques: robust primary replication, tightly contained chronic infection, and elicitation of potent immunity against the parental wild-type strain.
Mori K, Yasutomi Y, Ohgimoto S, Nakasone T, Takamura S, Shioda T, Nagai Y. Mori K, et al. Among authors: yasutomi y. J Virol. 2001 May;75(9):4023-8. doi: 10.1128/JVI.75.9.4023-4028.2001. J Virol. 2001. PMID: 11287551 Free PMC article.
180 results