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Large-Scale Whole-Genome Analysis of HTLV-1-Associated Myelopathy Identified Hereditary Spastic Paraplegias.
Takao N, Yagishita N, Araya N, Aratani S, Yamauchi J, Takahashi K, Kunitomo Y, Sato T, Nakamori M, Kawai Y, Omae Y, Tokunaga K, Matsuda F, Mitsuhashi S, Yamano Y. Takao N, et al. Among authors: kunitomo y. Neurol Genet. 2024 Jan 29;10(1):e200108. doi: 10.1212/NXG.0000000000200108. eCollection 2024 Feb. Neurol Genet. 2024. PMID: 38716326 Free PMC article.
Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1.
Tanaka Y, Sato T, Yagishita N, Yamauchi J, Araya N, Aratani S, Takahashi K, Kunitomo Y, Nagasaka M, Kanda Y, Uchimaru K, Morio T, Yamano Y. Tanaka Y, et al. Among authors: kunitomo y. Front Immunol. 2022 Aug 23;13:993025. doi: 10.3389/fimmu.2022.993025. eCollection 2022. Front Immunol. 2022. PMID: 36081501 Free PMC article.
Efficacy of Corticosteroid Therapy for HTLV-1-Associated Myelopathy: A Randomized Controlled Trial (HAMLET-P).
Yamauchi J, Tanabe K, Sato T, Nakagawa M, Matsuura E, Tsuboi Y, Tamaki K, Sakima H, Ishihara S, Ohta Y, Matsumoto N, Kono K, Yagishita N, Araya N, Takahashi K, Kunitomo Y, Nagasaka M, Coler-Reilly A, Hasegawa Y, Araujo A, Jacobson S, Grassi MFR, Galvão-Castro B, Bland M, Taylor GP, Martin F, Yamano Y. Yamauchi J, et al. Among authors: kunitomo y. Viruses. 2022 Jan 12;14(1):136. doi: 10.3390/v14010136. Viruses. 2022. PMID: 35062340 Free PMC article. Clinical Trial.
Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy.
Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y. Yamauchi J, et al. Among authors: kunitomo y. J Infect Dis. 2015 Jan 15;211(2):238-48. doi: 10.1093/infdis/jiu438. Epub 2014 Aug 7. J Infect Dis. 2015. PMID: 25104771
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y. Araya N, et al. Among authors: kunitomo y. J Clin Invest. 2014 Aug;124(8):3431-42. doi: 10.1172/JCI75250. Epub 2014 Jun 24. J Clin Invest. 2014. PMID: 24960164 Free PMC article.