Yao Y - Search Results

1

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB 3rd, Lee VM. Brunden KR, et al. Among authors: yao y. Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14. Pharmacol Res. 2011. PMID: 21163349 Free PMC article.

2

Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease.

Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Praticò D. Sung S, et al. Among authors: yao y. FASEB J. 2004 Feb;18(2):323-5. doi: 10.1096/fj.03-0961fje. Epub 2003 Dec 4. FASEB J. 2004. PMID: 14656990

3

12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress.

Praticò D, Zhukareva V, Yao Y, Uryu K, Funk CD, Lawson JA, Trojanowski JQ, Lee VM. Praticò D, et al. Among authors: yao y. Am J Pathol. 2004 May;164(5):1655-62. doi: 10.1016/S0002-9440(10)63724-8. Am J Pathol. 2004. PMID: 15111312 Free PMC article.

4

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.

Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, Longhi L, Trojanowski JQ, Lee VM, McIntosh TK, Praticò D. Conte V, et al. Among authors: yao y. J Neurochem. 2004 Aug;90(3):758-64. doi: 10.1111/j.1471-4159.2004.02560.x. J Neurochem. 2004. PMID: 15255955 Free article.

5

Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis.

Yao Y, Chinnici C, Tang H, Trojanowski JQ, Lee VM, Praticò D. Yao Y, et al. J Neuroinflammation. 2004 Oct 22;1(1):21. doi: 10.1186/1742-2094-1-21. J Neuroinflammation. 2004. PMID: 15500684 Free PMC article.

6

Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment.

Yao Y, Clark CM, Trojanowski JQ, Lee VM, Praticò D. Yao Y, et al. Ann Neurol. 2005 Oct;58(4):623-6. doi: 10.1002/ana.20558. Ann Neurol. 2005. PMID: 16037976

7

Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.

Ballatore C, Brunden KR, Piscitelli F, James MJ, Crowe A, Yao Y, Hyde E, Trojanowski JQ, Lee VM, Smith AB 3rd. Ballatore C, et al. Among authors: yao y. J Med Chem. 2010 May 13;53(9):3739-47. doi: 10.1021/jm100138f. J Med Chem. 2010. PMID: 20392114 Free PMC article.

8

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.

Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ. Brunden KR, et al. Among authors: yao y. J Neurosci. 2010 Oct 13;30(41):13861-6. doi: 10.1523/JNEUROSCI.3059-10.2010. J Neurosci. 2010. PMID: 20943926 Free PMC article.

9

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.

Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Brunden KR. Zhang B, et al. Among authors: yao y. J Neurosci. 2012 Mar 14;32(11):3601-11. doi: 10.1523/JNEUROSCI.4922-11.2012. J Neurosci. 2012. PMID: 22423084 Free PMC article.

10

Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties.

Ballatore C, Crowe A, Piscitelli F, James M, Lou K, Rossidivito G, Yao Y, Trojanowski JQ, Lee VM, Brunden KR, Smith AB 3rd. Ballatore C, et al. Among authors: yao y. Bioorg Med Chem. 2012 Jul 15;20(14):4451-61. doi: 10.1016/j.bmc.2012.05.027. Epub 2012 May 23. Bioorg Med Chem. 2012. PMID: 22717239 Free PMC article.

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