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Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer.
Ge Y, Weygant N, Qu D, May R, Berry WL, Yao J, Chandrakesan P, Zheng W, Zhao L, Zhao KL, Drake M, Vega KJ, Bronze MS, Tomasek JJ, An G, Houchen CW. Ge Y, et al. Among authors: yao j. Int J Cancer. 2018 Sep 1;143(5):1162-1175. doi: 10.1002/ijc.31400. Epub 2018 Apr 16. Int J Cancer. 2018. PMID: 29577277 Free PMC article.
DCLK1 Plays a Metastatic-Promoting Role in Human Breast Cancer Cells.
Liu H, Wen T, Zhou Y, Fan X, Du T, Gao T, Li L, Liu J, Yang L, Yao J, Ge Y, An G. Liu H, et al. Among authors: yao j. Biomed Res Int. 2019 May 15;2019:1061979. doi: 10.1155/2019/1061979. eCollection 2019. Biomed Res Int. 2019. PMID: 31223610 Free PMC article.
Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer.
Qu D, Weygant N, Yao J, Chandrakesan P, Berry WL, May R, Pitts K, Husain S, Lightfoot S, Li M, Wang TC, An G, Clendenin C, Stanger BZ, Houchen CW. Qu D, et al. Among authors: yao j. J Oncol. 2019 Aug 5;2019:6402925. doi: 10.1155/2019/6402925. eCollection 2019. J Oncol. 2019. PMID: 31467540 Free PMC article.
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