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IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC. Chan LC, et al. Among authors: yang wh, yang y. J Clin Invest. 2019 Jul 15;129(8):3324-3338. doi: 10.1172/JCI126022. eCollection 2019 Jul 15. J Clin Invest. 2019. PMID: 31305264 Free PMC article.
Deubiquitination and Stabilization of PD-L1 by CSN5.
Lim SO, Li CW, Xia W, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Lim SO, et al. Among authors: yang y. Cancer Cell. 2016 Dec 12;30(6):925-939. doi: 10.1016/j.ccell.2016.10.010. Epub 2016 Nov 17. Cancer Cell. 2016. PMID: 27866850 Free PMC article.
Palmitoylation stabilizes PD-L1 to promote breast tumor growth.
Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y, Hung MC. Yang Y, et al. Cell Res. 2019 Jan;29(1):83-86. doi: 10.1038/s41422-018-0124-5. Epub 2018 Dec 4. Cell Res. 2019. PMID: 30514902 Free PMC article. No abstract available.
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity.
Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS, Hung MC. Sun L, et al. Among authors: yang r, yang y. Cancer Res. 2020 Jun 1;80(11):2298-2310. doi: 10.1158/0008-5472.CAN-19-3133. Epub 2020 Mar 10. Cancer Res. 2020. PMID: 32156778 Free PMC article.
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