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Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability.
Gioelli N, Neilson LJ, Wei N, Villari G, Chen W, Kuhle B, Ehling M, Maione F, Willox S, Brundu S, Avanzato D, Koulouras G, Mazzone M, Giraudo E, Yang XL, Valdembri D, Zanivan S, Serini G. Gioelli N, et al. Among authors: yang xl. Nat Commun. 2022 Jul 20;13(1):4188. doi: 10.1038/s41467-022-31904-1. Nat Commun. 2022. PMID: 35858913 Free PMC article.
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality.
Zhou Q, Kapoor M, Guo M, Belani R, Xu X, Kiosses WB, Hanan M, Park C, Armour E, Do MH, Nangle LA, Schimmel P, Yang XL. Zhou Q, et al. Among authors: yang xl. Nat Struct Mol Biol. 2010 Jan;17(1):57-61. doi: 10.1038/nsmb.1706. Epub 2009 Dec 13. Nat Struct Mol Biol. 2010. PMID: 20010843 Free PMC article.
Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster.
Han GW, Yang XL, McMullan D, Chong YE, Krishna SS, Rife CL, Weekes D, Brittain SM, Abdubek P, Ambing E, Astakhova T, Axelrod HL, Carlton D, Caruthers J, Chiu HJ, Clayton T, Duan L, Feuerhelm J, Grant JC, Grzechnik SK, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kumar A, Marciano D, Miller MD, Morse AT, Nigoghossian E, Okach L, Paulsen J, Reyes R, van den Bedem H, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Elsliger MA, Schimmel P, Wilson IA. Han GW, et al. Among authors: yang xl. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1326-34. doi: 10.1107/S1744309110037619. Epub 2010 Sep 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20944229 Free PMC article.
tRNA-controlled nuclear import of a human tRNA synthetase.
Fu G, Xu T, Shi Y, Wei N, Yang XL. Fu G, et al. Among authors: yang xl. J Biol Chem. 2012 Mar 16;287(12):9330-4. doi: 10.1074/jbc.C111.325902. Epub 2012 Jan 30. J Biol Chem. 2012. PMID: 22291016 Free PMC article.
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
He W, Bai G, Zhou H, Wei N, White NM, Lauer J, Liu H, Shi Y, Dumitru CD, Lettieri K, Shubayev V, Jordanova A, Guergueltcheva V, Griffin PR, Burgess RW, Pfaff SL, Yang XL. He W, et al. Among authors: yang xl. Nature. 2015 Oct 29;526(7575):710-4. doi: 10.1038/nature15510. Epub 2015 Oct 21. Nature. 2015. PMID: 26503042 Free PMC article.
Studying nuclear functions of aminoacyl tRNA synthetases.
Shi Y, Wei N, Yang XL. Shi Y, et al. Among authors: yang xl. Methods. 2017 Jan 15;113:105-110. doi: 10.1016/j.ymeth.2016.09.011. Epub 2016 Sep 21. Methods. 2017. PMID: 27664293 Free PMC article.
1,565 results