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Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression.
Bai L, Qu W, Cheng X, Yang H, Huang YP, Wang Z, Han C, Tian RF, Hu F, Yang L, Tian S, Tian H, Cai Z, Wan J, Jiang J, Fu J, Zhou J, Hu Y, Ma T, Zhang X, Ji YX, Cai J, She ZG, Wang Y, Zhang P, Huang L, Li H, Zhang XJ. Bai L, et al. Among authors: yang l, yang h. Sci Transl Med. 2024 Feb 14;16(734):eade7347. doi: 10.1126/scitranslmed.ade7347. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38354227
A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques.
Zhang XJ, Ji YX, Cheng X, Cheng Y, Yang H, Wang J, Zhao LP, Huang YP, Sun D, Xiang H, Shen LJ, Li PL, Ma JP, Tian RF, Yang J, Yao X, Xu H, Liao R, Xiao L, Zhang P, Zhang X, Zhao GN, Wang X, Hu ML, Tian S, Wan J, Cai J, Ma X, Xu Q, Wang Y, Touyz RM, Liu PP, Loomba R, She ZG, Li H. Zhang XJ, et al. Among authors: yang h, yang j. Sci Transl Med. 2021 Dec 15;13(624):eabg8116. doi: 10.1126/scitranslmed.abg8116. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910548
A high-throughput drug screening identifies luteolin as a therapeutic candidate for pathological cardiac hypertrophy and heart failure.
Wang Z, Shi W, Wu T, Peng T, Wang X, Liu S, Yang Z, Wang J, Li PL, Tian R, Hong Y, Yang H, Bai L, Hu Y, Cheng X, Li H, Zhang XJ, She ZG. Wang Z, et al. Among authors: yang h, yang z. Front Cardiovasc Med. 2023 Mar 14;10:1130635. doi: 10.3389/fcvm.2023.1130635. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36998980 Free PMC article.
Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species.
Zhang XJ, Liu X, Hu M, Zhao GJ, Sun D, Cheng X, Xiang H, Huang YP, Tian RF, Shen LJ, Ma JP, Wang HP, Tian S, Gan S, Xu H, Liao R, Zou T, Ji YX, Zhang P, Cai J, Wang ZV, Meng G, Xu Q, Wang Y, Ma XL, Liu PP, Huang Z, Zhu L, She ZG, Zhang X, Bai L, Yang H, Lu Z, Li H. Zhang XJ, et al. Among authors: yang h. Cell Metab. 2021 Oct 5;33(10):2059-2075.e10. doi: 10.1016/j.cmet.2021.08.014. Epub 2021 Sep 17. Cell Metab. 2021. PMID: 34536344 Free article.
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