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Chronic hyperinsulinemia promotes human hepatocyte senescence.
Baboota RK, Spinelli R, Erlandsson MC, Brandao BB, Lino M, Yang H, Mardinoglu A, Bokarewa MI, Boucher J, Kahn CR, Smith U. Baboota RK, et al. Among authors: yang h. Mol Metab. 2022 Oct;64:101558. doi: 10.1016/j.molmet.2022.101558. Epub 2022 Jul 21. Mol Metab. 2022. PMID: 35872305 Free PMC article.
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Zeybel M, Altay O, Arif M, Li X, Yang H, Fredolini C, Akyildiz M, Saglam B, Gonenli MG, Ural D, Kim W, Schwenk JM, Zhang C, Shoaie S, Nielsen J, Uhlén M, Borén J, Mardinoglu A. Zeybel M, et al. Among authors: yang h. Mol Syst Biol. 2021 Oct;17(10):e10459. doi: 10.15252/msb.202110459. Mol Syst Biol. 2021. PMID: 34694070 Free PMC article. Clinical Trial.
Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis.
Zeybel M, Arif M, Li X, Altay O, Yang H, Shi M, Akyildiz M, Saglam B, Gonenli MG, Yigit B, Ulukan B, Ural D, Shoaie S, Turkez H, Nielsen J, Zhang C, Uhlén M, Borén J, Mardinoglu A. Zeybel M, et al. Among authors: yang h. Adv Sci (Weinh). 2022 Apr;9(11):e2104373. doi: 10.1002/advs.202104373. Epub 2022 Feb 7. Adv Sci (Weinh). 2022. PMID: 35128832 Free PMC article.
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning.
Zhang C, Shi M, Kim W, Arif M, Klevstig M, Li X, Yang H, Bayram C, Bolat I, Tozlu ÖÖ, Hacımuftuoglu A, Yıldırım S, Sebhaoui J, Iqbal S, Wei Y, Shi X, Nielsen J, Turkez H, Uhlen M, Boren J, Mardinoglu A. Zhang C, et al. Among authors: yang h. EBioMedicine. 2022 Sep;83:104214. doi: 10.1016/j.ebiom.2022.104214. Epub 2022 Aug 18. EBioMedicine. 2022. PMID: 35988463 Free PMC article.
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases.
Turkez H, Altay O, Yildirim S, Li X, Yang H, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Arif M, Yulug B, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Hacimuftuoglu A, Shoaie S, Zhang C, Nielsen J, Borén J, Uhlén M, Mardinoglu A. Turkez H, et al. Among authors: yang h. Life Sci. 2023 Feb 1;314:121325. doi: 10.1016/j.lfs.2022.121325. Epub 2022 Dec 26. Life Sci. 2023. PMID: 36581096 Free article.
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase.
Battisti UM, Gao C, Akladios F, Kim W, Yang H, Bayram C, Bolat I, Kiliclioglu M, Yuksel N, Tozlu OO, Zhang C, Sebhaoui J, Iqbal S, Shoaie S, Hacimuftuoglu A, Yildirim S, Turkez H, Uhlen M, Boren J, Mardinoglu A, Grøtli M. Battisti UM, et al. Among authors: yang h. Nutrients. 2023 Jan 22;15(3):577. doi: 10.3390/nu15030577. Nutrients. 2023. PMID: 36771285 Free PMC article.
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