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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Yanai A, et al. Nat Neurosci. 2006 Jun;9(6):824-31. doi: 10.1038/nn1702. Epub 2006 May 14. Nat Neurosci. 2006. PMID: 16699508 Free PMC article.
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, Hayden MR. Singaraja RR, et al. Among authors: yanai a. Hum Mol Genet. 2002 Nov 1;11(23):2815-28. doi: 10.1093/hmg/11.23.2815. Hum Mol Genet. 2002. PMID: 12393793
Intermolecular transmission of superoxide dismutase 1 misfolding in living cells.
Grad LI, Guest WC, Yanai A, Pokrishevsky E, O'Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR. Grad LI, et al. Among authors: yanai a. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16398-403. doi: 10.1073/pnas.1102645108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930926 Free PMC article.
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi LM, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR. Grad LI, et al. Among authors: yanai a. Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3620-5. doi: 10.1073/pnas.1312245111. Epub 2014 Feb 18. Proc Natl Acad Sci U S A. 2014. PMID: 24550511 Free PMC article.
An ex vivo gene therapy approach in X-linked retinoschisis.
Bashar AE, Metcalfe AL, Viringipurampeer IA, Yanai A, Gregory-Evans CY, Gregory-Evans K. Bashar AE, et al. Among authors: yanai a. Mol Vis. 2016 Jun 24;22:718-33. eCollection 2016. Mol Vis. 2016. PMID: 27390514 Free PMC article.
263 results