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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Ohashi T, Oguro Y, Tanaka T, Shiokawa Z, Tanaka Y, Shibata S, Sato Y, Yamakawa H, Hattori H, Yamamoto Y, Kondo S, Miyamoto M, Nishihara M, Ishimura Y, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: yamakawa h. Bioorg Med Chem. 2012 Sep 15;20(18):5507-17. doi: 10.1016/j.bmc.2012.07.034. Epub 2012 Jul 27. Bioorg Med Chem. 2012. PMID: 22898254
Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.
Ohashi T, Tanaka Y, Shiokawa Z, Banno H, Tanaka T, Shibata S, Satoh Y, Yamakawa H, Yamamoto Y, Hattori H, Kondo S, Miyamoto M, Tojo H, Baba A, Sasaki S. Ohashi T, et al. Among authors: yamakawa h. Bioorg Med Chem. 2015 Aug 1;23(15):4777-4791. doi: 10.1016/j.bmc.2015.05.036. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26094943
Body weight loss is a simple and useful indicator of prognosis and predictive tolerability in the first year of nintedanib therapy in patients with interstitial lung disease.
Yamakawa H, Sato S, Ohta H, Kusano K, Kawabe R, Oba T, Uzuka C, Sasaki H, Akasaka K, Amano M, Takemura T, Araya J, Matsushima H. Yamakawa H, et al. Respir Investig. 2024 Apr 24;62(4):551-557. doi: 10.1016/j.resinv.2024.04.011. Online ahead of print. Respir Investig. 2024. PMID: 38663299
A case of autoimmune pulmonary alveolar proteinosis during the course of treatment of rapidly progressive interstitial pneumonia associated with anti-MDA5 antibody-positive dermatomyositis.
Yatomi M, Akasaka K, Sato S, Chida M, Kanbe M, Sawada H, Yokota I, Wakamatsu I, Muto S, Sato M, Yamaguchi K, Miura Y, Tsurumaki H, Sakurai R, Hara K, Koga Y, Sunaga N, Yamakawa H, Matsushima H, Yamazaki S, Endo Y, Motegi SI, Hisada T, Maeno T. Yatomi M, et al. Among authors: yamakawa h. BMC Pulm Med. 2024 Apr 8;24(1):170. doi: 10.1186/s12890-024-02989-9. BMC Pulm Med. 2024. PMID: 38589870 Free PMC article.
516 results