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The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.
Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C. Weinberg DN, et al. Among authors: xu x. Nature. 2019 Sep;573(7773):281-286. doi: 10.1038/s41586-019-1534-3. Epub 2019 Sep 4. Nature. 2019. PMID: 31485078 Free PMC article.
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y, Goldberg EM, Chen X, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C. Li Y, et al. Among authors: xu x. Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi: 10.1016/j.molcel.2022.09.007. Epub 2022 Oct 6. Mol Cell. 2022. PMID: 36206767 Free PMC article.
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma.
Chen X, Li Y, Zhu F, Xu X, Estrella B, Pazos MA 2nd, McGuire JT, Karagiannis D, Sahu V, Mustafokulov M, Scuoppo C, Sánchez-Rivera FJ, Soto-Feliciano YM, Pasqualucci L, Ciccia A, Amengual JE, Lu C. Chen X, et al. Among authors: xu x. Nat Commun. 2023 Jul 17;14(1):4259. doi: 10.1038/s41467-023-39990-5. Nat Commun. 2023. PMID: 37460547 Free PMC article.
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.
Krug B, Hu B, Chen H, Ptack A, Chen X, Gretarsson KH, Deshmukh S, Kabir N, Andrade AF, Jabbour E, Harutyunyan AS, Lee JJY, Hulswit M, Faury D, Russo C, Xu X, Johnston MJ, Baguette A, Dahl NA, Weil AG, Ellezam B, Dali R, Blanchette M, Wilson K, Garcia BA, Soni RK, Gallo M, Taylor MD, Kleinman CL, Majewski J, Jabado N, Lu C. Krug B, et al. Among authors: xu x. bioRxiv [Preprint]. 2023 Nov 28:2023.11.28.567931. doi: 10.1101/2023.11.28.567931. bioRxiv. 2023. PMID: 38116029 Free PMC article. Preprint.
Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch.
Gretarsson KH, Abini-Agbomson S, Gloor SL, Weinberg DN, McCuiston JL, Kumary VUS, Hickman AR, Sahu V, Lee R, Xu X, Lipieta N, Flashner S, Adeleke OA, Popova IK, Taylor HF, Noll K, Windham CL, Maryanski DN, Venters BJ, Nakagawa H, Keogh MC, Armache KJ, Lu C. Gretarsson KH, et al. Among authors: xu x. bioRxiv [Preprint]. 2024 Mar 20:2024.03.18.585588. doi: 10.1101/2024.03.18.585588. bioRxiv. 2024. PMID: 38562823 Free PMC article. Preprint.
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