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ALS-linked C9orf72-SMCR8 complex is a negative regulator of primary ciliogenesis.
Tang D, Zheng K, Zhu J, Jin X, Bao H, Jiang L, Li H, Wang Y, Lu Y, Liu J, Liu H, Tang C, Feng S, Dong X, Xu L, Yin Y, Dang S, Wei X, Ren H, Dong B, Dai L, Cheng W, Wan M, Li Z, Chen J, Li H, Kong E, Wang K, Lu K, Qi S. Tang D, et al. Among authors: xu l. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2220496120. doi: 10.1073/pnas.2220496120. Epub 2023 Dec 8. Proc Natl Acad Sci U S A. 2023. PMID: 38064514
Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a.
Tang D, Sheng J, Xu L, Zhan X, Liu J, Jiang H, Shu X, Liu X, Zhang T, Jiang L, Zhou C, Li W, Cheng W, Li Z, Wang K, Lu K, Yan C, Qi S. Tang D, et al. Among authors: xu l. Proc Natl Acad Sci U S A. 2020 May 5;117(18):9876-9883. doi: 10.1073/pnas.2002110117. Epub 2020 Apr 17. Proc Natl Acad Sci U S A. 2020. PMID: 32303654 Free PMC article.
The C9orf72-SMCR8-WDR41 complex is a GAP for small GTPases.
Tang D, Sheng J, Xu L, Yan C, Qi S. Tang D, et al. Among authors: xu l. Autophagy. 2020 Aug;16(8):1542-1543. doi: 10.1080/15548627.2020.1779473. Epub 2020 Jun 17. Autophagy. 2020. PMID: 32521185 Free PMC article.
Efficacy and safety of pyrotinib combined with albumin-bound paclitaxel as first-line treatment for HER2-positive metastatic breast cancer in patients previously treated with adjuvant and/or neoadjuvant trastuzumab therapy: The stage 1 results of a single-arm, phase 2 prospective clinical trial.
Man X, Huang J, Sun S, Zhou D, Zhang B, Fang S, Zheng F, Li C, Wang X, Huang W, Wang L, He Q, Fu H, Zhang Y, Liu C, Dong L, Zhao X, Xu L, Sun X, Fan B, Song L, Zhou Z, Yu J, Li H. Man X, et al. Among authors: xu l. Clin Transl Med. 2024 May;14(5):e1687. doi: 10.1002/ctm2.1687. Clin Transl Med. 2024. PMID: 38738791 Clinical Trial.
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