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EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.
Xu K, Wu ZJ, Groner AC, He HH, Cai C, Lis RT, Wu X, Stack EC, Loda M, Liu T, Xu H, Cato L, Thornton JE, Gregory RI, Morrissey C, Vessella RL, Montironi R, Magi-Galluzzi C, Kantoff PW, Balk SP, Liu XS, Brown M. Xu K, et al. Among authors: xu h. Science. 2012 Dec 14;338(6113):1465-9. doi: 10.1126/science.1227604. Science. 2012. PMID: 23239736 Free PMC article.
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M. Wang Q, et al. Among authors: xu k. Cell. 2009 Jul 23;138(2):245-56. doi: 10.1016/j.cell.2009.04.056. Cell. 2009. PMID: 19632176 Free PMC article.
Nucleosome dynamics define transcriptional enhancers.
He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS. He HH, et al. Among authors: xu k. Nat Genet. 2010 Apr;42(4):343-7. doi: 10.1038/ng.545. Epub 2010 Mar 7. Nat Genet. 2010. PMID: 20208536 Free PMC article.
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis.
Wu Y, Zhang Z, Cenciarini ME, Proietti CJ, Amasino M, Hong T, Yang M, Liao Y, Chiang HC, Kaklamani VG, Jeselsohn R, Vadlamudi RK, Huang TH, Li R, De Angelis C, Fu X, Elizalde PV, Schiff R, Brown M, Xu K. Wu Y, et al. Among authors: xu k. Cancer Res. 2018 Feb 1;78(3):671-684. doi: 10.1158/0008-5472.CAN-17-1327. Epub 2017 Dec 6. Cancer Res. 2018. PMID: 29212856 Free PMC article.
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.
Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W. Wan L, et al. Among authors: xu k. Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024. Mol Cell. 2018. PMID: 29351847 Free PMC article.
Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress.
Liao Y, Chen CH, Xiao T, de la Peña Avalos B, Dray EV, Cai C, Gao S, Shah N, Zhang Z, Feit A, Xue P, Liu Z, Yang M, Lee JH, Xu H, Li W, Mei S, Pierre RS, Shu S, Fei T, Duarte M, Zhao J, Bradner JE, Polyak K, Kantoff PW, Long H, Balk SP, Liu XS, Brown M, Xu K. Liao Y, et al. Among authors: xu k, xu h. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2105898119. doi: 10.1073/pnas.2105898119. Proc Natl Acad Sci U S A. 2022. PMID: 35031563 Free PMC article.
Differential impact of RB status on E2F1 reprogramming in human cancer.
McNair C, Xu K, Mandigo AC, Benelli M, Leiby B, Rodrigues D, Lindberg J, Gronberg H, Crespo M, De Laere B, Dirix L, Visakorpi T, Li F, Feng FY, de Bono J, Demichelis F, Rubin MA, Brown M, Knudsen KE. McNair C, et al. Among authors: xu k. J Clin Invest. 2018 Jan 2;128(1):341-358. doi: 10.1172/JCI93566. Epub 2017 Dec 4. J Clin Invest. 2018. PMID: 29202480 Free PMC article.
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