Xu JH - Search Results

1

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation.

Zhang YZ, Chen X, Fan XX, He JX, Huang J, Xiao DK, Zhou YL, Zheng SY, Xu JH, Yao XJ, Liu L, Leung EL. Zhang YZ, et al. Among authors: xu jh. Molecules. 2016 Mar 18;21(3):374. doi: 10.3390/molecules21030374. Molecules. 2016. PMID: 26999101 Free PMC article.

2

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations.

Wang Q, Li Y, Xu J, Wang Y, Leung EL, Liu L, Yao X. Wang Q, et al. Sci Rep. 2017 Aug 18;7(1):8857. doi: 10.1038/s41598-017-08909-8. Sci Rep. 2017. PMID: 28821780 Free PMC article.

3

Novel direct AMPK activator suppresses non-small cell lung cancer through inhibition of lipid metabolism.

Chen X, Xie C, Fan XX, Jiang ZB, Wong VK, Xu JH, Yao XJ, Liu L, Leung EL. Chen X, et al. Among authors: xu jh. Oncotarget. 2017 Oct 9;8(56):96089-96102. doi: 10.18632/oncotarget.21716. eCollection 2017 Nov 10. Oncotarget. 2017. PMID: 29221189 Free PMC article.

4

Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening.

Wang Q, Xu J, Li Y, Huang J, Jiang Z, Wang Y, Liu L, Leung ELH, Yao X. Wang Q, et al. Front Pharmacol. 2018 Mar 1;9:173. doi: 10.3389/fphar.2018.00173. eCollection 2018. Front Pharmacol. 2018. PMID: 29545752 Free PMC article.

5

Identification of a potent kinase inhibitor targeting EML4-ALK fusion protein in non-small cell lung cancer.

Luo LX, Li Y, Niu YZ, Wang YW, Wang QQ, Fan XX, Xu JH, Liu L, Leung EL, Yao XJ. Luo LX, et al. Among authors: xu jh. Medchemcomm. 2017 Aug 25;8(10):1914-1918. doi: 10.1039/c7md00305f. eCollection 2017 Oct 1. Medchemcomm. 2017. PMID: 30108712 Free PMC article.

6

Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains.

Wang Q, An X, Xu J, Wang Y, Liu L, Leung EL, Yao X. Wang Q, et al. Org Biomol Chem. 2018 Sep 11;16(35):6521-6530. doi: 10.1039/c8ob01526k. Org Biomol Chem. 2018. PMID: 30160288

7

Computational study on the selective inhibition mechanism of MS402 to the first and second bromodomains of BRD4.

Wang Q, Li Y, Xu J, Wang Y, Shi D, Liu L, Leung EL, Yao X. Wang Q, et al. Proteins. 2019 Jan;87(1):3-11. doi: 10.1002/prot.25611. Epub 2018 Nov 13. Proteins. 2019. PMID: 30260047

8

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer.

Xu J, Wang Q, Leung ELH, Li Y, Fan X, Wu Q, Yao X, Liu L. Xu J, et al. Front Med. 2020 Feb;14(1):60-67. doi: 10.1007/s11684-019-0694-8. Epub 2019 May 18. Front Med. 2020. PMID: 31104301

9

Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer.

Wang Y, Tang C, Yao S, Lai H, Li R, Xu J, Wang Q, Fan XX, Wu QB, Leung EL, Ye Y, Yao X. Wang Y, et al. Phytomedicine. 2019 Dec;65:153100. doi: 10.1016/j.phymed.2019.153100. Epub 2019 Sep 27. Phytomedicine. 2019. PMID: 31648127

10

Artificial intelligence-based collaborative filtering method with ensemble learning for personalized lung cancer medicine without genetic sequencing.

Luo S, Xu J, Jiang Z, Liu L, Wu Q, Leung EL, Leung AP. Luo S, et al. Pharmacol Res. 2020 Oct;160:105037. doi: 10.1016/j.phrs.2020.105037. Epub 2020 Jun 23. Pharmacol Res. 2020. PMID: 32590103

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