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A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, McBride JD, Duan J, Deng J, Zhang B, Kim SJ, Zoll B, Saito T, Sasaguri H, Saido TC, Ballatore C, Yao H, Wang Z, Trojanowski JQ, Brunden KR, Lee VM, He Z. Zhao X, et al. Among authors: xu h. Sci Transl Med. 2023 Sep 13;15(713):eabo6889. doi: 10.1126/scitranslmed.abo6889. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703352 Free PMC article.
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils.
Gibbons GS, Banks RA, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM. Gibbons GS, et al. Among authors: xu h. J Neurosci. 2017 Nov 22;37(47):11485-11494. doi: 10.1523/JNEUROSCI.2393-17.2017. Epub 2017 Oct 6. J Neurosci. 2017. PMID: 28986461 Free PMC article.
Transmission of tauopathy strains is independent of their isoform composition.
He Z, McBride JD, Xu H, Changolkar L, Kim SJ, Zhang B, Narasimhan S, Gibbons GS, Guo JL, Kozak M, Schellenberg GD, Trojanowski JQ, Lee VM. He Z, et al. Among authors: xu h. Nat Commun. 2020 Jan 7;11(1):7. doi: 10.1038/s41467-019-13787-x. Nat Commun. 2020. PMID: 31911587 Free PMC article.
α-Synuclein modulates tau spreading in mouse brains.
Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM. Bassil F, et al. Among authors: xu h. J Exp Med. 2021 Jan 4;218(1):e20192193. doi: 10.1084/jem.20192193. J Exp Med. 2021. PMID: 33091110 Free PMC article.
Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery.
Hunter M, Spiller KJ, Dominique MA, Xu H, Hunter FW, Fang TC, Canter RG, Roberts CJ, Ransohoff RM, Trojanowski JQ, Lee VM. Hunter M, et al. Among authors: xu h. Acta Neuropathol Commun. 2021 Aug 19;9(1):140. doi: 10.1186/s40478-021-01239-x. Acta Neuropathol Commun. 2021. PMID: 34412701 Free PMC article.
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