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Genomewide CRISPR knockout screen identified PLAC8 as an essential factor for SADS-CoVs infection.
Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2118126119. doi: 10.1073/pnas.2118126119. Epub 2022 Apr 27.
Proc Natl Acad Sci U S A. 2022.
PMID: 35476513
Free PMC article.
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration.
Morrison CB, Shaffer KM, Araba KC, Markovetz MR, Wykoff JA, Quinney NL, Hao S, Delion MF, Flen AL, Morton LC, Liao J, Hill DB, Drumm ML, O'Neal WK, Kesimer M, Gentzsch M, Ehre C.
Morrison CB, et al. Among authors: wykoff ja.
Eur Respir J. 2022 Feb 3;59(2):2100185. doi: 10.1183/13993003.00185-2021. Print 2022 Feb.
Eur Respir J. 2022.
PMID: 34172469
Free PMC article.
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SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13.
Morrison CB, Edwards CE, Shaffer KM, Araba KC, Wykoff JA, Williams DR, Asakura T, Dang H, Morton LC, Gilmore RC, O'Neal WK, Boucher RC, Baric RS, Ehre C.
Morrison CB, et al. Among authors: wykoff ja.
Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2119680119. doi: 10.1073/pnas.2119680119. Epub 2022 Mar 30.
Proc Natl Acad Sci U S A. 2022.
PMID: 35353667
Free PMC article.
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Rapid Viscoelastic Characterization of Airway Mucus Using a Benchtop Rheometer.
Wykoff JA, Shaffer KM, Araba KC, Markovetz MR, Patarin J, Robert de Saint Vincent M, Donaldson SH, Ehre C.
Wykoff JA, et al.
J Vis Exp. 2022 Apr 21;(182). doi: 10.3791/63876.
J Vis Exp. 2022.
PMID: 35532240
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Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration.
Mikami Y, Grubb BR, Rogers TD, Dang H, Asakura T, Kota P, Gilmore RC, Okuda K, Morton LC, Sun L, Chen G, Wykoff JA, Ehre C, Vilar J, van Heusden C, Livraghi-Butrico A, Gentzsch M, Button B, Stutts MJ, Randell SH, O'Neal WK, Boucher RC.
Mikami Y, et al. Among authors: wykoff ja.
Sci Transl Med. 2023 Jun 7;15(699):eabo7728. doi: 10.1126/scitranslmed.abo7728. Epub 2023 Jun 7.
Sci Transl Med. 2023.
PMID: 37285404
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SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia.
Meganck RM, Edwards CE, Mallory ML, Lee RE, Dang H, Bailey AB, Wykoff JA, Gallant SC, Zhu DR, Yount BL, Kato T, Shaffer KM, Nakano S, Cawley AM, Sontake V, Wang JR, Hagan RS, Miller MB, Tata PR, Randell SH, Tse LV, Ehre C, Okuda K, Boucher RC, Baric RS.
Meganck RM, et al. Among authors: wykoff ja.
Cell Rep. 2024 Apr 23;43(4):114076. doi: 10.1016/j.celrep.2024.114076. Epub 2024 Apr 10.
Cell Rep. 2024.
PMID: 38607917
Free article.
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