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Hypomorphic GINS3 variants alter DNA replication and cause Meier-Gorlin syndrome.
McQuaid ME, Ahmed K, Tran S, Rousseau J, Shaheen R, Kernohan KD, Yuki KE, Grover P, Dreseris ES, Ahmed S, Dupuis L, Stimec J, Shago M, Al-Hassnan ZN, Tremblay R, Maass PG, Wilson MD, Grunebaum E, Boycott KM, Boisvert FM, Maddirevula S, Faqeih EA, Almanjomi F, Khan ZU, Alkuraya FS, Campeau PM, Kannu P, Campos EI, Wurtele H. McQuaid ME, et al. Among authors: wurtele h. JCI Insight. 2022 May 23;7(10):e155648. doi: 10.1172/jci.insight.155648. JCI Insight. 2022. PMID: 35603789 Free PMC article.
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.
Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sánchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington L. Benslimane Y, et al. Among authors: wurtele h. Mol Cell. 2020 Sep 3;79(5):846-856.e8. doi: 10.1016/j.molcel.2020.07.010. Epub 2020 Aug 4. Mol Cell. 2020. PMID: 32755594 Free article.
A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response.
Lemay JF, St-Hilaire E, Ronato DA, Gao Y, Bélanger F, Gezzar-Dandashi S, Kimenyi Ishimwe AB, Sawchyn C, Lévesque D, McQuaid M, Boisvert FM, Mallette FA, Masson JY, Drobetsky EA, Wurtele H. Lemay JF, et al. Among authors: wurtele h. PLoS Biol. 2022 Oct 10;20(10):e3001543. doi: 10.1371/journal.pbio.3001543. eCollection 2022 Oct. PLoS Biol. 2022. PMID: 36215310 Free PMC article.
An open-source algorithm for rapid unbiased determination of DNA fiber length.
Ghesquière P, Elsherbiny A, Fortier E, McQuaid M, Mazzaferri J, Bélanger F, Cheriet F, Drobetsky E, Wurtele H, Costantino S. Ghesquière P, et al. Among authors: wurtele h. DNA Repair (Amst). 2019 Feb;74:26-37. doi: 10.1016/j.dnarep.2019.01.003. Epub 2019 Jan 11. DNA Repair (Amst). 2019. PMID: 30665830
Chromatin dynamics and DNA replication roadblocks.
Hammond-Martel I, Verreault A, Wurtele H. Hammond-Martel I, et al. Among authors: wurtele h. DNA Repair (Amst). 2021 Aug;104:103140. doi: 10.1016/j.dnarep.2021.103140. Epub 2021 May 23. DNA Repair (Amst). 2021. PMID: 34087728 Review.
Starvation-induced proteasome assemblies in the nucleus link amino acid supply to apoptosis.
Uriarte M, Sen Nkwe N, Tremblay R, Ahmed O, Messmer C, Mashtalir N, Barbour H, Masclef L, Voide M, Viallard C, Daou S, Abdelhadi D, Ronato D, Paydar M, Darracq A, Boulay K, Desjardins-Lecavalier N, Sapieha P, Masson JY, Sergeev M, Kwok BH, Hulea L, Mallette FA, Milot E, Larrivée B, Wurtele H, Affar EB. Uriarte M, et al. Among authors: wurtele h. Nat Commun. 2021 Nov 30;12(1):6984. doi: 10.1038/s41467-021-27306-4. Nat Commun. 2021. PMID: 34848715 Free PMC article.
SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability.
Yates M, Marois I, St-Hilaire E, Ronato DA, Djerir B, Brochu C, Morin T, Hammond-Martel I, Gezzar-Dandashi S, Casimir L, Drobetsky E, Cappadocia L, Masson JY, Wurtele H, Maréchal A. Yates M, et al. Among authors: wurtele h. PLoS Biol. 2024 Mar 19;22(3):e3002552. doi: 10.1371/journal.pbio.3002552. eCollection 2024 Mar. PLoS Biol. 2024. PMID: 38502677 Free PMC article.
42 results